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首页> 外文期刊>Journal of International Medical Research >Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer: Meta-analysis using Mendelian randomization
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Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer: Meta-analysis using Mendelian randomization

机译：基因降低循环中sRAGE的浓度可能会增加患癌症的风险：使用孟德尔随机化的荟萃分析

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Objectives To undertake a systematic meta-analysis of all variants in the gene encoding receptor for advanced glycation end products ( RAGE ) to summarize their associations with cancer risk and changes in the levels of circulating soluble RAGE (sRAGE), with the aim of determining possible causality between circulating sRAGE and cancer risk. Methods Articles written in English were retrieved from MEDLINE? and EMBASE? databases. Two researchers independently identified eligible articles and extracted the data (analysed using STATA? software version 12.0). Results Fifteen articles qualified for inclusion in the meta-analysis of the RAGE –cancer association and three examined the RAGE –sRAGE relationship. The 82Ser/82Ser genotype was significantly associated with overall cancer risk compared with the 82Gly/Gly genotype (odds ratio 1.75, 95% confidence interval [CI] 1.46, 2.10). Carriers of the 82Ser/82Ser genotype had significantly reduced circulating sRAGE concentrations compared with the 82Gly/82Gly genotype. Mendelian randomization analysis demonstrated that a reduction of 100, 200 and 300?pg/ml in circulating sRAGE concentrations was associated with a 1.11-fold (95% CI 1.06, 1.25), 1.24-fold (95% CI 1.11, 1.57) and 1.38-fold (95% CI 1.18, 1.96) increased risk of developing cancer, respectively. Conclusions Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer.
机译：目的对晚期糖基化终产物（RAGE）的编码受体基因的所有变体进行系统的荟萃分析，以总结其与癌症风险和循环可溶性RAGE（sRAGE）水平变化的关系。循环sRAGE与癌症风险之间的因果关系。方法从MEDLINE检索英文文章。和EMBASE？数据库。两名研究人员独立确定了合格的文章并提取了数据（使用STATA？12.0版软件进行了分析）。结果有15篇文章符合RAGE-癌症关联性荟萃分析的资格，其中3篇检查了RAGE-sRAGE关系。与82Gly / Gly基因型相比，82Ser / 82Ser基因型与总体癌症风险显着相关（优势比1.75，95％置信区间[CI] 1.46，2.10）。与82Gly / 82Gly基因型相比，82Ser / 82Ser基因型的携带者的循环sRAGE浓度显着降低。孟德尔随机分析表明，循环sRAGE浓度降低100、200和300µpg / ml分别与1.11倍（95％CI 1.06、1.25），1.24倍（95％CI 1.11、1.57）和1.38相关（95％CI 1.18，1.96）分别增加患癌症的风险。结论从基因上降低循环中sRAGE的浓度可能会增加患癌的风险。

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