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首页> 外文期刊>Journal of King Saud University >Malaria: Patterns of relapse and resistance
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Malaria: Patterns of relapse and resistance

机译：疟疾：复发和抵抗的模式

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Malaria constitutes persistent threat to the human health and remains a distinct cause of morbidity and mortality, 40% of the world population is at risk of exposure to this menace in 100 countries (WHO, 2001). Present data represents the registered cases of malaria in the hospitals and clinics in India. Plasmodium vivax and Plasmodium falciparum infections were recorded 63.86%, 66.06%, 62.58% and 36.13%, 33.93%, 37.41%, respectively, amongst individuals with symptoms of intermittent high fever for three days. Maximum transmission with highest slide positivity rates (SPR) 61.76% and 50.14% was periodically and strategically observed during September and October while lowest yearly transmission slide positivity rates (SPR) (19.60–24.07%) was estimated in the months of March and April. Average relapse rates (ARR) in P. vivax was recorded 17.1%. Short term relapses were more recurring than the long term in the ratio of 4:1. Eighty-eight patients who were administered with total of 1500 mg chloroquine and 75 mg primaquine through divided doses also showed relapse rate of 4.5%. Patients suffering from falciparum malaria showed resistance against chloroquine in 10.6% cases after getting 1500 mg chloroquine based on divided doses (i.e. 600 mg on day 1 and 300 mg after 8 h and followed by 300 mg daily for 2 days.).
机译：疟疾对人类健康构成持续威胁，仍然是发病率和死亡率的一个独特原因，全世界100％的国家有40％的人有遭受这种威胁的危险（世界卫生组织，2001年）。当前数据代表了印度医院和诊所登记的疟疾病例。在连续三天出现间歇性高烧症状的个体中，间日疟原虫和恶性疟原虫感染分别记录为63.86％，66.06％，62.58％和36.13％，33.93％，37.41％。在9月和10月定期并策略性地观察到最大滑动率（SPR）为61.76％和50.14％的最高传播率，而3月和4月则估计最低的年度传播滑动率（SPR）（19.60-24.07％）。间日疟原虫的平均复发率（ARR）为17.1％。短期复发比长期复发的比例更高，为4：1。分次服用总共1500 mg氯喹和75 mg primaquine的88位患者的复发率也为4.5％。恶性疟疾患者在分剂量服用1500 mg氯喹后（即第1天为600 mg，8小时后为300 mg，然后每天300 mg，共2天）显示出对氯喹的耐药性，占10.6％的情况。

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