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首页> 外文期刊>Journal of King Saud University >Biological effects of Naja haje crude venom on the hepatic and renal tissues of mice
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Biological effects of Naja haje crude venom on the hepatic and renal tissues of mice

机译： Naja haje 粗毒液对小鼠肝肾组织的生物学作用

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摘要

Snake venoms are known to cause different metabolic disorders, altering cellular and enzymatic activities in animals and releasing pharmacological substances. In this study, the lethality as well as biochemical and histopathological effect of Egyptian cobra ( Naja haje ; N. haje ) crude venom at a sublethal dose have been investigated on liver and kidney of male mice. Venom injected intramuscularly in mice with 1/2 LD50 (approximately 0.0115 μg/g body weight of mice) and the animals were sacrificed 6 days post injection. Results indicated that the injection of crude venom of the N. haje induced a significant disturbance in liver and kidney functions. In addition, results revealed that N. haje venom has a potent oxidative activity by increasing the level of reactive oxygen species with concomitant significant increase in hydrogen peroxide, lipid peroxidation, carbonyl protein and nitric oxide levels in hepatic and renal tissues. This activity was extended to decrease non-enzymatic and enzymatic antioxidant defense components such as glutathione, superoxide dismutase and catalase. Additionally, the biochemical alternations induced in hepatic and renal tissues were associated with significant alternations in the histological architecture of liver and kidney of injected mice. From this study, we can conclude that such injury could be considered among the factors that lead to death caused by N. haje venom.
机译：已知蛇毒会引起不同的代谢紊乱，改变动物的细胞和酶活性并释放药理物质。在这项研究中，已研究了亚致死剂量的埃及眼镜蛇（Naja haje; N。haje）粗毒液对雄性小鼠肝脏和肾脏的致死性以及生化和组织病理学作用。用1/2 LD50（约0.0115μg/ g小鼠体重）向小鼠肌肉内注射毒液，并在注射后6天处死动物。结果表明，注射的哈氏猪笼草粗毒液引起肝脏和肾脏功能的明显紊乱。此外，结果表明，通过增加活性氧的含量，海带猪笼草毒液具有强大的氧化活性，同时肝和肾组织中过氧化氢，脂质过氧化，羰基蛋白和一氧化氮的含量也显着增加。扩展该活性以减少非酶和酶抗氧化剂防御成分，例如谷胱甘肽，超氧化物歧化酶和过氧化氢酶。另外，在肝和肾组织中诱导的生化改变与注射小鼠的肝脏和肾脏的组织学结构的显着改变有关。从这项研究中，我们可以得出结论，可以考虑将此类伤害视为导致哈吉猪笼草毒液致死的因素之一。

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