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首页> 外文期刊>Journal of International Medical Research >Effects of Mexiletine on the Haemodynamic Responses to Tracheal Intubation
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Effects of Mexiletine on the Haemodynamic Responses to Tracheal Intubation

机译：美西律汀对气管插管血液动力学反应的影响

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摘要

The efficacy of intravenous mexiletine in attenuating the cardiovascular responses to laryngoscopy and tracheal intubation was studied in 30 normotensive patients undergoing elective surgery. The patients were randomly allocated to one of three treatment groups: saline (n = 10); 2 mg/kg mexiletine (n = 10); and 3 mg/kg mexiletine (n = 10). The placebo/mexiletine was administered immediately before induction of anaesthesia using 5 mg/kg thiopentone and tracheal intubation was facilitated with 0.2 mg/kg vecuronium; laryngoscopy lasting 30 s was attempted 2 min after induction of anaesthesia. All groups showed a significant (P < 0.05) increase in mean arterial pressure and heart rate associated with tracheal intubation. The increase in mean arterial pressure was significantly (P < 0.05) smaller in patients receiving 3 mg/kg mexiletine compared with those receiving either saline or 2 mg/kg mexiletine. There was no significant attenuation in heart rate in either of the mexiletine treatment groups compared with the saline group. It is concluded that 3 mg/kg mexiletine given intravenously provides a simple and effective method for attenuating the pressor response to laryngoscopy and tracheal intubation.
机译：在30例接受择期手术的血压正常患者中，研究了静脉注射美西律对减轻对喉镜和气管插管的心血管反应的功效。将患者随机分配到三个治疗组之一：生理盐水（n = 10）;生理盐水（n = 10）。 2 mg / kg美西律（n = 10）;和3 mg / kg美西律（n = 10）。在使用5 mg / kg硫代戊酮麻醉诱导前，立即给予安慰剂/美西律，并用0.2 mg / kg维库溴铵促进气管插管。麻醉诱导后2分钟尝试进行持续30 s的喉镜检查。所有组均显示与气管插管相关的平均动脉压和心率显着（P <0.05）升高。与接受生理盐水或2 mg / kg美西律的患者相比，接受3 mg / kg美西律的患者的平均动脉压升高显着（P <0.05）。与盐水组相比，美西律治疗组中的任何一个都没有明显的心率衰减。结论是静脉内给予3 mg / kg美西律提供了一种简单有效的方法来减轻对喉镜和气管插管的升压反应。

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