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首页> 外文期刊>Journal of International Medical Research >A Comparison of High-Level Aminoglycoside Resistance in Vancomycin-Sensitive and Vancomycin-Resistant Enterococcus Species
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A Comparison of High-Level Aminoglycoside Resistance in Vancomycin-Sensitive and Vancomycin-Resistant Enterococcus Species

机译：万古霉素敏感和耐万古霉素肠球菌对高水平氨基糖苷耐药性的比较

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摘要

The aim of this study was to investigate whether there was a significant difference in high-level aminoglycoside resistance (HLAR) between vancomycin-sensitive enterococci (VSE) and vancomycin-resistant enterococci (VRE). Vancomycin resistance was determined in 116 Enterococcus isolates using brain-heart infusion agar containing 6 μg/ml vancomycin. HLAR was determined by both standard agar screening and disk diffusion methods. Streptomycin and gentamicin were used as predictors of HLAR. Vancomycin resistance and HLAR were found in 17 (14.7%) and 41 (35.3%) of the Enterococcus strains, respectively. HLAR was found in 11 of 17 VRE and 30 of 98 VSE strains. HLAR in VRE strains was significantly higher than in VSE. More enterococcal strains were found to be resistant to both gentamicin and streptomycin (29) than to gentamicin (one) or streptomycin (11) alone. The HLAR rate in VRE was two-fold higher than in VSE. The synergistic bactericidal effect of aminoglycosides and β-lactam or glycopeptide antibiotics is lost if there is high-level resistance to aminoglycosides.
机译：这项研究的目的是调查在对万古霉素敏感的肠球菌（VSE）和对万古霉素耐药的肠球菌（VRE）之间高水平氨基糖苷耐药性（HLAR）是否存在显着差异。使用含有6μg/ ml万古霉素的脑心浸液琼脂测定116株肠球菌中的万古霉素耐药性。通过标准琼脂筛查和圆盘扩散法测定HLAR。链霉素和庆大霉素被用作HLAR的预测因子。在肠球菌菌株中分别发现了万古霉素耐药性和HLAR，分别为17（14.7％）和41（35.3％）。在17个VRE菌株中的11个和98个VSE菌株中的30个中发现了HLAR。 VRE菌株的HLAR显着高于VSE。发现与单独的庆大霉素（一种）或链霉素（11）相比，更多的肠球菌菌株对庆大霉素和链霉素都具有耐药性（29）。 VRE中的HLAR率是VSE中的两倍。如果对氨基糖苷类药物有高度耐药性，则氨基糖苷类药物与β-内酰胺或糖肽类抗生素的协同杀菌作用将丧失。

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