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首页> 外文期刊>Journal of International Medical Research >Factors affecting recovery from anaesthesia with propofol–remifentanil target-controlled infusion in laparoscopic surgery
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Factors affecting recovery from anaesthesia with propofol–remifentanil target-controlled infusion in laparoscopic surgery

机译：腹腔镜手术中丙泊酚-瑞芬太尼靶控输注麻醉后恢复的影响因素

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Objective This study was performed to analyse factors influencing the effect-site concentration (Ce) of propofol at return of consciousness (ROC) with target-controlled infusion of propofol–remifentanil after laparoscopic surgery. Methods In total, 112 patients who underwent laparoscopic surgery under general anaesthesia were given propofol at the target concentration of 3.5?μg/ml. Remifentanil (Ce: 4.0?ng/ml) and 0.9?mg/kg of rocuronium were administered when the Observer’s Assessment of Alertness/Sedation score reached 1. Two minutes after injection of rocuronium, tracheal intubation was initiated. The bispectral index (BIS) was maintained between 45 and 55. Results Ce values of propofol at loss of consciousness (LOC) and ROC were significantly correlated. Age was significantly correlated with Ce of propofol at ROC. At LOC, propofol Ce values of patients aged 65–80, 45–64, and 20–44 years were 1.8?±?0.8, 2.2?±?0.7, and 2.3?±?0.8?μg/ml, respectively, and the BIS was 70?±?10, 68?±?7, and 69?±?10, respectively. At ROC, the propofol Ce values of the three groups were 1.2?±?0.3, 1.4?±?0.3, and 1.5?±?0.3?μg/ml, respectively, and the BIS was 80?±?5, 82?±?6, and 83?±?6, respectively. Conclusions The concentration of propofol at ROC was significantly affected by age, and ROC of propofol–remifentanil anaesthesia after laparoscopic surgery was well predicted by the concentration at LOC.
机译：目的本研究分析腹腔镜手术后靶控输注丙泊酚-瑞芬太尼后意识恢复（ROC）时影响丙泊酚作用部位浓度（Ce）的因素。方法对112例行全麻腹腔镜手术的患者给予丙泊酚，目标浓度为3.5μg/ ml。当观察者的机敏性/镇静评分达到1时，给予瑞芬太尼（Ce：4.0？ng / ml）和0.9？mg / kg罗库溴铵。在注射罗库溴铵后两分钟，开始气管插管。双光谱指数（BIS）维持在45至55之间。结果失去知觉（LOC）和ROC时异丙酚的Ce值显着相关。在中华民国，年龄与丙泊酚的铈含量显着相关。在LOC，65-80岁，45-64岁和20-44岁患者的丙泊酚Ce值分别为1.8？±？0.8、2.2？±？0.7和2.3？±？0.8？μg/ ml，而BIS分别为70±±10、68±±7和69±±10。在ROC下，三组的异丙酚Ce值分别为1.2？±？0.3、1.4？±？0.3和1.5？±？0.3？μg/ ml，BIS为80？±？5、82？±分别为6和83±6。结论年龄显着影响ROC中丙泊酚的浓度，LOC浓度可很好地预测腹腔镜手术后丙泊酚-瑞芬太尼麻醉的ROC。

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