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首页> 外文期刊>Journal of International Medical Research >High acute phase protein levels correlate with pulmonary and skin involvement in patients with diffuse systemic sclerosis
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High acute phase protein levels correlate with pulmonary and skin involvement in patients with diffuse systemic sclerosis

机译：弥漫性系统性硬化症患者的急性期蛋白水平高与肺和皮肤受累有关

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Objective This study was performed to evaluate the serum amyloid A (SAA) and C-reactive protein (CRP) levels in patients with diffuse systemic sclerosis (dSSc) in relation to a control group, disease duration, and skin and pulmonary involvement. Methods This case-control study included 18 patients with early dSSc, 15 patients with late dSSc, and 15 healthy controls. The SAA and CRP levels, modified Rodnan skin score (mRSS), and diffusing capacity of the lungs for carbon monoxide (DLCO) were determined in all patients. Results The SAA and CRP levels were significantly higher in patients with early and late dSSc than in healthy controls. The frequency of detection of elevated SAA and CRP levels was approximately 66% and 85%, respectively. A significant correlation was found between the SAA and CRP levels in patients with dSSc. The SAA and CRP levels were inversely correlated with DLCO. The CRP level was positively correlated with the mRSS. Conclusions High SAA and CRP levels could serve as biomarkers for pulmonary involvement. The serum CRP level accurately reflects the extension of skin thickening in patients with dSSc.
机译：目的进行本研究以评估与对照组，疾病持续时间以及皮肤和肺部受累有关的弥漫性系统性硬化症（dSSc）患者的血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）水平。方法该病例对照研究包括18例早期dSSc患者，15例晚期dSSc患者和15名健康对照。确定所有患者的SAA和CRP水平，改良的Rodnan皮肤评分（mRSS）以及肺对一氧化碳的扩散能力（DLCO）。结果早期和晚期dSSc患者的SAA和CRP水平显着高于健康对照组。检测到SAA和CRP水平升高的频率分别约为66％和85％。发现dSSc患者的SAA和CRP水平之间存在显着相关性。 SAA和CRP水平与DLCO呈负相关。 CRP水平与mRSS呈正相关。结论高的SAA和CRP水平可以作为肺部受累的生物标志物。血清CRP水平准确反映了dSSc患者皮肤增厚的程度。

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