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首页> 外文期刊>Journal of King Saud University >Remedial effects of casticin as an antioxidant on cisplatin induced oxidative damage in rat liver
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Remedial effects of casticin as an antioxidant on cisplatin induced oxidative damage in rat liver

机译：黄ic素作为抗氧化剂对顺铂诱导的大鼠肝脏氧化损伤的修复作用

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Cisplatin (CP) is an active cytotoxic agent, which has been verified to be effective in multiple cancer regimen. In this study, potential antioxidant effects of casticin (CAS) were assessed against CP generated oxidative stress in rat liver. “Twenty-four male Sprague Dawley rats were divided into four experimental groups. Group-1 (control group) received only normal saline”. Group-2 was intraperitoneally injected with CP (10?mg/kg). Group-3 was orally provided by CAS (50?mg/kg) along with CP (10?mg/kg) injection at first day. Group-4 group was orally administered with CAS (50?mg/kg) throughout the experiment. The rats of group-1 indicated “increase in serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), while a significant decrease in the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD)” was noticed, which revealed that CP generated oxidative stress in rat liver. Moreover, administration of CP increased the hydrogen peroxide (H2O2) concentration and level of “thiobarbituric acid reactive substances (TBARS)”, while reducing the % DNA head and head length in liver cell nuclei. CP disturbs the lobular structure of the liver and increased the sinusoidal dilation in rat liver. However, co-treatment with CAS successfully mitigated the CP generated DNA disruption, biochemical and pathological changes in rat liver. These findings revealed that an effective antioxidant, CAS, alleviated the CP generated hepatotoxicity and oxidative stress in rats.
机译：顺铂（CP）是一种活性细胞毒剂，已被证明在多种癌症治疗方案中均有效。在这项研究中，针对大鼠肝脏中CP产生的氧化应激，评估了Casticin（CAS）的潜在抗氧化作用。 “将24只雄性Sprague Dawley大鼠分为四个实验组。第一组（对照组）仅接受生理盐水”。第2组腹膜内注射CP（10？mg / kg）。第3组由CAS（50？mg / kg）和CP（10？mg / kg）注射在第一天口服。在整个实验过程中，第4组口服CAS（50？mg / kg）。第一组的大鼠表明“血清中的天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）水平升高，而过氧化氢酶（CAT），超氧化物歧化酶（SOD）和过氧化物酶（POD）”被注意到，这表明CP在大鼠肝脏中产生氧化应激。此外，CP的使用增加了过氧化氢（H2O2）的浓度和“硫代巴比妥酸反应性物质（TBARS）”的水平，同时减少了肝细胞核中DNA头和头长度的百分比。 CP会扰乱肝脏的小叶结构，并增加大鼠肝脏的正弦波扩张。然而，与CAS的共同治疗成功减轻了CP产生的大鼠肝脏DNA破坏，生化和病理变化。这些发现表明，有效的抗氧化剂CAS减轻了CP所产生的肝毒性和大鼠氧化应激。

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