• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Lipid Research >Weekday variation in triglyceride concentrations in 1.8 million blood samples
【24h】

Weekday variation in triglyceride concentrations in 1.8 million blood samples

机译：一百八十万血液样本中甘油三酸酯浓度的平日变化

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Triglyceride (TG) concentration is used as a marker of cardiometabolic risk. However, diurnal and possibly weekday variation exists in TG concentrations. The objective of this work was to investigate weekday variation in TG concentrations among 1.8 million blood samples drawn between 2008 and 2015 from patients in the Capital region of Denmark. Plasma TG was extracted from a central clinical laboratory information system. Weekday variation was investigated by means of linear mixed models. In addition to the profound diurnal variation, the TG concentration was 4.5% lower on Fridays compared with Mondays (P 0.0001). The variation persisted after multiple adjustments for confounders and was consistent across all sensitivity analyses. Out-patients and in-patients, respectively, had 5.0% and 1.9% lower TG concentrations on Fridays compared with Mondays (both P 0.0001). The highest weekday variations in TG concentrations were recorded for out-patients between the ages of 9 and 26 years, with up to 20% higher values on Mondays compared with Fridays (all P 0.05). In conclusion, TG concentrations were highest after the weekend and gradually declined during the week. We suggest that unhealthy food intake and reduced physical activity during the weekend increase TG concentrations which track into the week. This weekday variation may carry implications for public health and future research practice.
机译：甘油三酸酯（TG）浓度用作心脏代谢风险的标志。但是，TG浓度存在昼夜变化，甚至可能是平日变化。这项工作的目的是调查在2008年至2015年之间从丹麦首都地区的患者抽取的180万份血液样本中TG浓度的工作日变化。血浆TG是从中央临床实验室信息系统中提取的。通过线性混合模型研究了工作日的变化。除日间变化很大外，星期五的TG含量比星期一低4.5％（P <0.0001）。在对混杂因素进行多次调整后，差异仍然存在，并且在所有敏感性分析中均保持一致。与星期一相比，星期五的门诊病人和住院病人的TG浓度分别降低了5.0％和1.9％（均P <0.0001）。在9至26岁的门诊患者中，TG的最高工作日变化记录最高，与星期一相比，星期一的最高值高出20％（所有P <0.05）。总之，TG浓度在周末后最高，而在一周内逐渐下降。我们建议周末不健康的食物摄入和减少体育锻炼会增加TG的浓度，而TG的浓度会持续到一周。这个工作日的变化可能会对公共卫生和未来的研究实践产生影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号