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首页> 外文期刊>Journal of International Medical Research >Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt
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Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt

机译：上埃及阿瑟特儿童戊型肝炎病毒感染的发生率和特征

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Objective To describe the characteristics of hepatitis E virus (HEV) infection in a cohort of children from Upper Egypt using data from a large multicentre prospective study of acute viral hepatitis (AVH). Methods Data from subjects aged 2–18?years with AVH or close contacts of those with AVH found to have asymptomatic AVH were included in the analysis. Information concerning medical history, clinical examination, liver function tests and screening for hepatotropic viruses was recorded and analysed. Results A total of 123 patients (73 boys, 50 girls) were included in the analysis. Of these, 33 (26.8%) had HEV infection, 17 (13.8%) had hepatitis A virus infection, 10 (8.1%) had hepatitis B virus infection, 14 (11.4%) had cytomegalovirus hepatitis, five (4.1%) had autoimmune hepatitis, 11 (8.9%) had hepatitis due to mixed viral infections and 33 (26.8%) had non A–E hepatitis. Overall, 38 (30.9%) had infection with HEV. HEV infection was significantly higher among those using underground wells as a water source compared with tap water. Liver enzymes were significantly raised in patients with non-HEV infection compared with those with HEV infection. Conclusions HEV is a significant cause of AVH among children in Upper Egypt. Contamination of drinking water appears to be a major source of infection. Screening for HEV should be considered in all Egyptian children with AVH.
机译：目的使用来自大型急性病毒性肝炎（AVH）的多中心前瞻性研究数据，描述上埃及儿童队列中的戊型肝炎病毒（HEV）感染特征。方法该分析包括2-18岁的AVH受试者或被发现无症状的AVH的密切接触者的数据。记录并分析有关病史，临床检查，肝功能检查和肝炎病毒筛查的信息。结果本研究共纳入123例患者（男73例，女50例）。其中33例（26.8％）患有HEV感染，17例（13.8％）患有甲型肝炎病毒感染，10例（8.1％）患有乙型肝炎病毒感染，14例（11.4％）患有巨细胞病毒性肝炎，5例（4.1％）患有自身免疫肝炎，其中11例（8.9％）因混合病毒感染而患肝炎，33例（26.8％）非A–E肝炎。总体而言，有38（30.9％）人感染了HEV。与自来水相比，使用地下井作为水源的人中，戊型肝炎病毒感染明显更高。与非HEV感染患者相比，非HEV感染患者的肝酶显着升高。结论HEV是上埃及儿童中AVH的重要原因。饮用水的污染似乎是主要的感染源。所有埃及AVH患儿均应考虑筛查HEV。

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