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首页> 外文期刊>Journal of International Medical Research >Prospective cohort study of the risk factors for stress fractures in Chinese male infantry recruits
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Prospective cohort study of the risk factors for stress fractures in Chinese male infantry recruits

机译：中国男性步兵新兵应力性骨折危险因素的前瞻性队列研究

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Objective To determine potential risk factors that could predict stress fractures over an 8-week basic military training in Chinese male infantry recruits. Methods Recruits from three infantry units enrolled in this prospective study. At baseline, demographic data, personal history of stress fractures, mean duration of weekly exercise and smoking history were recorded on questionnaires and blood samples taken for analysis of bone turnover biomarkers and genetic factors. Results Of the 1516 male recruits who volunteered to participate in the study, 1398 recruits provided data for analysis. In total, 189 stress fracture cases were observed (incidence rate: 13.5%) during the 8-week training period. Recruits with stress fractures had a significantly higher incidence of prior fracture history and lower exercise level prior to enrolment compared with those without stress fractures. A significant difference in both allelic frequency and genotypic distribution of the growth differentiation factor 5 ( GDF5 ) gene rs143383 polymorphism was observed between recruits with and without stress fractures. However, no difference in serum bone turnover biomarkers was detected between groups. Conclusion This prospective, cohort study indicates that fracture history, lower exercise level and GDF5 rs143383 may be predictive risk factors for stress fractures in Chinese male infantry recruits.
机译：目的确定潜在的危险因素，这些因素可以预测中国男步兵新兵在为期8周的基础军事训练中的应力性骨折。方法从该前瞻性研究中招募的三个步兵单位招募。在基线时，人口统计数据，个人压力性骨折的病史，每周运动的平均持续时间和吸烟史都记录在调查表和血液样本中，用于分析骨转换生物标志物和遗传因素。结果在自愿参加研究的1516名男性新兵中，有1398名新兵提供了分析数据。在为期8周的训练期内，共观察到189例应力性骨折病例（发生率：13.5％）。与无应力性骨折的新兵相比，有应力性骨折的新兵有较高的既往骨折史和较低的运动水平。在有或没有应力性骨折的新兵之间，观察到生长分化因子5（GDF5）基因rs143383多态性的等位基因频率和基因型分布均存在显着差异。但是，两组之间没有发现血清骨转换生物标志物的差异。结论这项前瞻性队列研究表明，骨折史，较低的运动水平和GDF5 rs143383可能是中国男兵新兵应激性骨折的预测危险因素。

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