Proprotein convertase FURIN regulates T cell receptor‐induced transactivation

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Proprotein convertase FURIN regulates T cell receptor‐induced transactivation

机译：前蛋白转化酶FURIN调节T细胞受体诱导的反式激活

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AntigenemergencerapidlystimulatesTcells,whichleadstochangesincytokineproduction,cellproliferation,anddifferentiation.Someofthekeymoleculesinvolvedintheseevents,suchasTGF‐β1andNOTCH1,aresynthesizedinitiallyasinactiveprecursorsandareproteolyticallyactivatedduringTcellactivation.PCSKsregulateproproteinmaturationbycatalyzingtheproteolyticcleavageoftheirsubstrates.TheprototypePCSKFURINisinduceduponTCRactivation,anditsexpressioninTcellsiscriticalforthemaintenanceofperipheralimmunetolerance.Inthisstudy,wetestedthehypothesisthatFURINregulatesTcellactivation.OurdatademonstratethatIL‐2isincreasedinitiallyinFURIN‐deficientmouseCD4+Tcells,buttheTCR‐inducedIL‐2mRNAexpressionisnotsustainedintheabsenceofFURIN.Accordingly,theinhibitionofFURINinhumanJurkatTcelllinesalsoresultsinadecreaseinIL‐2production,whereastheoverexpressionofWTFURINisassociatedwithelevatedIL‐2levels.InJurkatcells,FURINisdispensableforimmediateTCRsignalingsteps,suchasERK,ZAP70,orLATphosphorylation.However,withtheuseofgenereporterassays,wedemonstratethatFURINregulatestheAP‐1,NFAT,andNF‐κBtranscriptionfactors.Finally,byperformingatranscriptionfactor‐bindingsiteenrichmentanalysisonFURIN‐dependenttranscriptomes,weidentifytheFURIN‐regulatedtranscriptionfactorsinmouseCD4+Tcellsubsets.Collectively,ourworkconfirmsthehypothesisthattheTCR‐regulatedproteaseFURINplaysanimportantroleinTcellactivationandthatitcanspecificallymodulateTCR‐activatedtransactivation...

机译：AntigenemergencerapidlystimulatesTcells，whichleadstochangesincytokineproduction，细胞增殖，anddifferentiation.Someofthekeymoleculesinvolvedintheseevents，suchasTGF-β1andNOTCH1，aresynthesizedinitiallyasinactiveprecursorsandareproteolyticallyactivatedduringTcellactivation.PCSKsregulateproproteinmaturationbycatalyzingtheproteolyticcleavageoftheirsubstrates.TheprototypePCSKFURINisinduceduponTCRactivation，anditsexpressioninTcellsiscriticalforthemaintenanceofperipheralimmunetolerance.Inthisstudy，wetestedthehypothesisthatFURINregulatesTcellactivation.OurdatademonstratethatIL-2isincreasedinitiallyinFURIN-deficientmouseCD4 + T细胞，buttheTCR-inducedIL-2mRNAexpressionisnotsustainedintheabsenceofFURIN.Accordingly，theinhibitionofFURINinhumanJurkatTcelllinesalsoresultsinadecreaseinIL-2production，whereastheoverexpressionofWTFURINisassociatedwithelevatedIL-2levels。在Jurkatcells中，FURIN是立即进行的TCR信号转送步骤，例如ERK，ZAP70或LAT磷酸化。但是，使用基因报告程序没错，我们希望证明FURIN调节AP-1，NFAT和NF-κB转录因子。最后，通过对FURIN依赖的转录组进行转录因子结合位点富集分析，我们确定了FURIN调控的转录因子在CD4 + T细胞亚基上被小鼠激活了CD4 + T细胞亚基。

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2015年第1期|共11页
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1. Proprotein convertase FURIN regulates T cell receptor-induced transactivation [J] . Ortutay Zsuzsanna, Oksanen Anna, Aittomaki Saara, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2015,第1期

机译：前蛋白转化酶FURIN调节T细胞受体诱导的反式激活
2. T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development [J] . Vahatupa Maria, Aittomaki Saara, Cordova Zuzet Martinez, Oncoimmunology. . 2016,第12期

机译：T细胞表达的ProProtein转化酶Furin抑制DMBA / TPA诱导的皮肤癌症发育
3. Proprotein convertase furin regulates osteocalcin and bone endocrine function [J] . Omar Al Rifai, Jacqueline Chow, Julie Lacombe, The journal of clinical investigation . 2017,第11期

机译：前蛋白转化酶弗林蛋白酶调节骨钙素和骨内分泌功能
4. A novel bioactive inhibitor of proprotein convertase furin that contains a beta-turn inducing enediyne amino acid [C] . Ajoy Basak, Amit Basak International Peptide Symposium;European Peptide Symposium . 2005

机译：一种新型生物活性抑制作用的Proprotein转化酶Furin，其含有诱导enediyne氨基酸的β-转弯
5. Evaluation of the Interaction Between Proprotein Convertase Subtilisin/Kexin Type 9 and Sterol Carrier Protein-2 [D] . Ahranjani, Reza. 2017

机译：评价前蛋白转化酶枯草杆菌蛋白酶/ Kexin 9型与甾醇载体蛋白2的相互作用。
6. Proprotein Convertase Furin Regulates Apoptosis and Proliferation of Granulosa Cells in the Rat Ovary [O] . Xiaokui Yang, Qingxin Wang, Zhiying Gao, 2010

机译：前蛋白转化酶弗林蛋白酶调节大鼠卵巢颗粒细胞的凋亡和增殖。
7. Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. [O] . Xiaokui Yang, Qingxin Wang, Zhiying Gao, 2013

机译：前蛋白转化酶弗林蛋白酶调节大鼠卵巢中颗粒细胞的凋亡和增殖。

Proprotein convertase FURIN regulates T cell receptor‐induced transactivation

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