The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

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The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

机译：M1和M2巨噬细胞的趋化性受不同趋化因子的调节

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Thehomingofproinflammatory(M1)andthe“alternativelyactivated”anti‐inflammatory(M2)macrophagesplaysadifferentroleintheprocessofinflammation.Chemokinesarethemajormediatorsofmacrophagechemotaxis,buthowtheydifferentiallyregulateM1andM2macrophagesremainslargelyunclear.Inthepresentstudy,weattemptedtoscreenchemokinesthatdifferentiallyinducechemotaxisofM1andM2macrophagesandtoexploretheunderlyingmechanism.Amongthe41chemokinesthatspecificallybindto20chemokinereceptors,CCL19,CCL21,CCL24,CCL25,CXCL8,CXCL10,andXCL2specificallyinducedM1macrophagechemotaxis,whereasCCL7inducedchemotaxisofbothM1andM2macrophages.WhereasthedifferentialeffectsofthesechemokinesonM1/M2macrophagechemotaxiscouldbeattributabletothepredominantexpressionoftheircognatereceptorsonthemacrophagesubsets,CCR7,thereceptorforCCL19/CCL21,appearedtobeanexception.ImmunoblotanalysisindicatedanequivalentlevelofCCR7inthewholecelllysateofM1andM2macrophages,butCCL19andCCL21onlyinducedM1macrophagechemotaxis.BothimmunoblotandconfocalmicroscopyanalysesdemonstratedthatCCR7waspredominantlyexpressedonthecellsurfaceofM1butinthecytosolofM2macrophagesbeforeligandstimulation.Asaresult,CCL19orCCL21inducedactivationofbothMEK1‐ERK1/2andPI3K‐AKTcascadesinM1butnotinM2macrophages.Intriguingly,CCL19/CCL21‐mediatedM1macrophagechemotaxiswasblockedbyspecificinhibitionofPI3KratherthanMEK1.Together,thesefindingssuggestthatrecruitmentofM1andM2macrophagesisfinetunedbydifferentchemokineswiththeinvolvementofspecificsignalingpathways...

机译：Thehomingofproinflammatory（M1）以及所述“alternativelyactivated”消炎（M2）macrophagesplaysadifferentroleintheprocessofinflammation.Chemokinesarethemajormediatorsofmacrophagechemotaxis，buthowtheydifferentiallyregulateM1andM2macrophagesremainslargelyunclear.Inthepresentstudy，weattemptedtoscreenchemokinesthatdifferentiallyinducechemotaxisofM1andM2macrophagesandtoexploretheunderlyingmechanism.Amongthe41chemokinesthatspecificallybindto20chemokinereceptors，CCL19，CCL21，CCL24，CCL25，CXCL8，CXCL10，andXCL2specificallyinducedM1macrophagechemotaxis，whereasCCL7inducedchemotaxisofbothM1andM2macrophages.WhereasthedifferentialeffectsofthesechemokinesonM1 / M2macrophagechemotaxiscouldbeattributabletothepredominantexpressionoftheircognatereceptorsonthemacrophagesubsets，CCR7，thereceptorforCCL19 / CCL21，似乎是豆类异常。免疫印迹分析表明，M1和M2巨噬细胞的整个细胞溶解物中CCR7的水平相等，但CCL19和CCL21仅诱导M1巨噬细胞的趋化性。 ysesdemonstratedthatCCR7waspredominantlyexpressedonthecellsurfaceofM1butinthecytosolofM2macrophagesbeforeligandstimulation.Asaresult，CCL19orCCL21inducedactivationofbothMEK1-ERK1 / 2andPI3K-AKTcascadesinM1butnotinM2macrophages.Intriguingly，CCL19 / CCL21-mediatedM1macrophagechemotaxiswasblockedbyspecificinhibitionofPI3KratherthanMEK1.Together，thesefindingssuggestthatrecruitmentofM1andM2macrophagesisfinetunedbydifferentchemokineswiththeinvolvementofspecificsignalingpathways ...

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2015年第1期|共9页
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1. The chemotaxis of M1 and M2 macrophages is regulated by different chemokines [J] . Xuan Wenjuan, Qu Qing, Zheng Biao, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2015,第1期

机译：M1和M2巨噬细胞的趋化性受不同趋化因子的调节
2. Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages [J] . Amrita D Joshi, Sameer R Oak, Adam J Hartigan, BMC Immunology . 2010,第1期

机译：白细胞介素33有助于人类巨噬细胞中M1和M2趋化因子标志物的表达
3. Umbelliprenin Increases the M1/M2 Ratio of Macrophage Polarization and Improves the M1 Macrophage Activity in THP-1 Cells Cocultured with AGS Cells [J] . MohammadTaher Bahrami, Mostafa Haji Molla Hoseini, Mitra Rezaei, Evidence-based complementary and alternative medicine: eCAM . 2021,第a期

机译：umbelliprenin增加巨噬细胞极化的M1 / M2比，并改善了与AGS细胞共同的THP-1细胞中的M1巨噬细胞活性
4. LncRNA GAS5 Inhibits Progression of Colorectal Cancer by Regulating M1/M2 Macrophages Polarization [C] . Linyu Tang, Quanpeng Li, Xianxiu Ge, International Symposium on the Frontiers of Biotechnology and Bioengineering . 2019

机译：通过调节M1 / M2巨噬细胞极化，LNCRNA Gas5抑制结肠直肠癌的进展
5. M1 and M2 macrophages promote muscle injury and repair during muscular dystrophy [D] . Villalta, Sergio Armando. 2009

机译：M1和M2巨噬细胞在肌营养不良期间促进肌肉损伤和修复
6. Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages [O] . Amrita D Joshi, Sameer R Oak, Adam J Hartigan, 2010

机译：白细胞介素33有助于人类巨噬细胞中的M1和M2趋化因子标志物的表达
7. Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages [O] . Joshi, Amrita D, Oak, Sameer R, Hartigan, Adam J, 2015

机译：白细胞介素-33有助于人巨噬细胞中m1和m2趋化因子标记物的表达

The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

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