VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast–maternal leukocyte interaction

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VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast–maternal leukocyte interaction

机译：VIP在滋养层细胞与母体白细胞相互作用的体外模型中促进滋养层细胞对调节性T细胞的诱导

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InducibleregulatoryTcells(Tregs)exertatimelyandefficientimmunosuppressiveactionatthecriticalperi‐implantationstageessentialformaternaltolerancetotheconceptus.Vasoactiveintestinalpeptide(VIP)promotesanti‐inflammatoryandtolerogenicprofilesthroughbindingtoVIPreceptorsonimmunecells.WeevaluatedwhetherVIPproducedbytrophoblastcellsinducesTregsduringtheearlyinteractionofmaternalleukocyteswithtrophoblastcells,thuscontributingtomaternaltolerance.Weusedaninvitromodelofmaternalleukocyte–trophoblastcellinteractionrepresentedbycoculturesoffertilewomen'sPBMCswithahumantrophoblastcellline(Swan‐71)andevaluatedtheeffectofVIPaddedexogenouslyandoftheendogenouspolypeptide.VIPincreasedthefrequencyofCD4+CD25+FoxP3+cellsaftercoculture,andthesecellswereabletosuppressthematernalalloresponse.VIPalsoincreasedthefrequencyofCD4+IL10+andCD4+TGFβ+cells,butitdidnotmodulateIFN‐γorIL‐17production.Swan‐71secretedVIP,andtheircoculturewithmaternalPBMCssignificantlyincreasedthefrequencyofTregs.ThiseffectwasevenmorepronouncedifthetrophoblastcellshadbeenpretreatedwithVIP.Inbothsituations,theVIPantagonistpreventedtheincreaseinthefrequencyofCD4+Foxp3+cells,reflectingaspecificeffectofthepolypeptideaftertheinteractionwithSwan‐71cells.Finally,theincreaseinCD4+CD25+FoxP3+frequencywaspreventedbyananti–TGF‐βAbandaVIPantagonist.TheseresultssuggestthatVIPcouldhaveanactiveroleintheimmunoregulatoryprocessesoperatinginthematernal–placentalinterfacebycontributingtotheinductionofTregsthroughamechanisminvolvingTGF‐β1...

机译：InducibleregulatoryTcells（Treg细胞）exertatimelyandefficientimmunosuppressiveactionatthecriticalperi-implantationstageessentialformaternaltolerancetotheconceptus.Vasoactiveintestinalpeptide（VIP）promotesanti-inflammatoryandtolerogenicprofilesthroughbindingtoVIPreceptorsonimmunecells.WeevaluatedwhetherVIPproducedbytrophoblastcellsinducesTregsduringtheearlyinteractionofmaternalleukocyteswithtrophoblastcells，thuscontributingtomaternaltolerance.Weusedaninvitromodelofmaternalleukocyte-trophoblastcellinteractionrepresentedbycoculturesoffertilewomen'sPBMCswithahumantrophoblastcellline（天鹅-71）andevaluatedtheeffectofVIPaddedexogenouslyandoftheendogenouspolypeptide.VIPincreasedthefrequencyofCD4 + CD25 + FoxP3的+ cellsaftercoculture，andthesecellswereabletosuppressthematernalalloresponse.VIPalsoincreasedthefrequencyofCD4 + IL10 + andCD4 +TGFβ+ Swan-71分泌了VIP，并且与母体PBMC的共培养显着增加了Tregs的频率。天鹅绒71分泌的VIP明显地增加了Tregs的频率。 difthetrophoblastcellshadbeenpretreatedwithVIP.Inbothsituations，theVIPantagonistpreventedtheincreaseinthefrequencyofCD4 + FOXP3 +细胞，reflectingaspecificeffectofthepolypeptideaftertheinteractionwithSwan-71cells.Finally，theincreaseinCD4 + CD25 + FOXP3 + frequencywaspreventedbyananti TGF-βAbandaVIPantagonist.TheseresultssuggestthatVIPcouldhaveanactiveroleintheimmunoregulatoryprocessesoperatinginthematernal-placentalinterfacebycontributingtotheinductionofTregsthroughamechanisminvolvingTGF-β1...

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2015年第1期|共10页
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1. VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast-maternal leukocyte interaction [J] . Fraccaroli Laura, Grasso Esteban, Hauk Vanesa, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2015,第1期

机译：VIP在滋养层细胞与母体白细胞相互作用的体外模型中促进滋养层细胞对调节性T细胞的诱导
2. An in vitro coculture model to study cytokine profiles of natural killer cells during maternal immune cell-trophoblast interactions. [J] . Ntrivalas E, Kwak-Kim J, Beaman K, Journal of the Society for Gynecologic Investigation . 2006,第3期

机译：体外共培养模型，用于研究母体免疫细胞与滋养细胞相互作用期间自然杀伤细胞的细胞因子谱。
3. Induction of p38 mitogen-activated protein kinase-mediated apoptosis is involved in outgrowth of trophoblast cells on endometrial epithelial cells in a model of human trophoblast-endometrial interactions [J] . Li HY., Chang SP., Yuan CC., Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction . 2003,第5期

机译：在人类滋养细胞-子宫内膜相互作用模型中，诱导p38丝裂原活化的蛋白激酶介导的细胞凋亡与滋养细胞在子宫内膜上皮细胞上的生长有关
4. Evolution of the interferon T genes and their promoters, and maternal-trophoblast interactions in control of their expression [C] . R. M. Roberts, T. Ezashi, C. S. Rosenfeld, International Symposium on Reproduction in Domestic Ruminants . 2003

机译：干扰素T基因及其启动子的演变，以及母中滋养流细胞相互作用控制其表达
5. Using a Real-Time Cellular Biosensor to Investigate in vitro Liver Culture Models; Exploring the Effect of Primary Cultures, Cell to Cell Interaction in Co-culture, and Cell to Extracellular Matrix Interactions [D] . Ciampa, Grace. 2019

机译：使用实时细胞生物传感器来研究体外肝培养模型;探讨原发性培养物，细胞对共培养细胞相互作用的影响，以及细胞对细胞基质相互作用
6. VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast–maternal leukocyte interaction [O] . Laura Fraccaroli, Esteban Grasso, Vanesa Hauk, -1

机译：VIP在滋养层细胞与母体白细胞相互作用的体外模型中促进滋养层细胞对调节性T细胞的诱导
7. Differential influence of maternal and fetal pregnancy factors on the in-vitro induction of human regulatory T cells: a preliminary study. [O] . Marcoli Natalie, Østensen Monika, Portmann-Lanz C Bettina, 2015

机译：孕产妇和胎儿妊娠因子对人调节性T细胞体外诱导的差异影响：一项初步研究。

VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast–maternal leukocyte interaction

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