首页> 外国专利> methods for screening a molecule capable of binding to cd4, to produce a therapeutic composition, to screen an antibody or antibody fragment, in vitro for activating cd4 + cd25 + regulatory t cells, to treat an individual, and to screen for the presence of cd4 + cd25 + regulatory cells in a sample, therapeutic composition, antibody or antibody fragment, isolated peptide, isolated peptide mimotope, nucleic acid, vector, host cell or hybridoma, uses of an antibody or antibody fragment of the isolated peptide and a cd4 + cd25 + regulatory t cell, cd4 + cd25 + regulatory t cell, and kit.

methods for screening a molecule capable of binding to cd4, to produce a therapeutic composition, to screen an antibody or antibody fragment, in vitro for activating cd4 + cd25 + regulatory t cells, to treat an individual, and to screen for the presence of cd4 + cd25 + regulatory cells in a sample, therapeutic composition, antibody or antibody fragment, isolated peptide, isolated peptide mimotope, nucleic acid, vector, host cell or hybridoma, uses of an antibody or antibody fragment of the isolated peptide and a cd4 + cd25 + regulatory t cell, cd4 + cd25 + regulatory t cell, and kit.

机译：筛选能够与cd4结合的分子，产生治疗性组合物，筛选抗体或抗体片段，体外活化cd4 + cd25 +调节性t细胞，治疗个体以及筛选cd4的方法样品中的+ cd25 +调节细胞，治疗组合物，抗体或抗体片段，分离的肽，分离的肽模拟表位，核酸，载体，宿主细胞或杂交瘤，分离的肽的抗体或抗体片段和cd4 + cd25的用途+调节性t细胞，cd4 + cd25 +调节性t细胞和试剂盒。

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method for screening a molecule capable of binding to cd4 to produce a therapeutic composition for screening an antibody or antibody fragment capable of binding cd4 to produce an antibody or antibody fragment in vitro for activation of regulatory t cells cd4 + cd25 +, to treat an individual, and to screen for the presence of cd4 + cd25 + regulatory cells in a sample, therapeutic composition, antibody or antibody fragment, isolated peptide, an isolated peptide mimotope, nucleic acid, vector, host cell or hybridoma, uses of an antibody or antibody fragment, the isolated peptide and a cd4.cd25 + regulatory t cell, cd4 + cd25 + regulatory t cell, and kit. screening methods are provided for identifying molecules capable of binding to cd4 and capable of activating cd4 + cd25 + regulatory t cells. Antibodies and antibody fragments capable of activating cd4 + cd25 + regulatory t cells and methods and uses involving the antibodies and fragments thereof are also provided.

机译：筛选能够与cd4结合的分子以产生治疗组合物的方法，所述治疗组合物用于筛选能够与cd4结合以产生抗体或抗体片段的抗体或抗体片段在体外用于激活调节性t细胞cd4 + cd25 +的方法，以治疗个体，并筛选样品，治疗组合物，抗体或抗体片段，分离的肽，分离的肽模拟表位，核酸，载体，宿主细胞或杂交瘤，抗体或抗体的用途中cd4 + cd25 +调节细胞的存在片段，分离的肽和cd4.cd25 +调节性t细胞，cd4 + cd25 +调节性t细胞和试剂盒。提供了用于鉴定能够结合cd4并且能够激活cd4 + cd25 +调节性t细胞的分子的筛选方法。还提供了能够激活cd4 + cd25 +调节性t细胞的抗体和抗体片段，以及涉及该抗体及其片段的方法和用途。

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公开/公告号BR112012012911A2

专利类型
公开/公告日2016-10-25

原文格式PDF
申请/专利权人 BIOTEST AG;
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申请/专利号BR20121112911
发明设计人 ANDRÉ ENGLING;BENJAMIN DAEKLEN;CHANTAL ZUBER;CHRISTOPH BRUECHER;CHRISTOPH UHEREK;FRANK OSTERROTH;GREGOR SCHULZ;HOLGER WALLMEIER;KIRSTEN VÖLP;NIKLAS CZELOTH;
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申请日2010-11-30
分类号C07K16/28;G01N33/50;
国家 BR
入库时间 2022-08-21 14:27:28

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