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首页> 外文会议>International Symposium on VIP, PACAP, and Related Peptides >Vasoactive Intestinal Peptide Generates CD4~+CD25~+ Regulatory T Cells in vivo:Therapeutic Applications in Autoimmunity and Transplantation
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Vasoactive Intestinal Peptide Generates CD4~+CD25~+ Regulatory T Cells in vivo:Therapeutic Applications in Autoimmunity and Transplantation

机译：血管活性肠肽在体内产生CD4〜+ CD25〜+调节性T细胞：自身免疫和移植中的治疗应用

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CD4~+ CD25~+ regulatory T cells (T_(reg)) control the immune response to a variety of antigens, including self-antigens, and several models support the idea of the peripheral generation of CD4~+CD25~+ T_(reg) from CD4~+ CD25~– T cells. However, little is known about the endogenous factors and mechanisms controlling the peripheral expansion of CD4~+ CD25~+ T_(reg). We have found that the immunosuppressive neuropeptide vasoactive intestinal peptide (VIP) induces functional Treg in vivo. The administration of VIP together with specific antigen to TCR-transgenic mice results in the expansion of the CD4~+ CD25~+, Foxp-3/neuropilin 1-expressing T cells, which inhibit responder T cell proliferation through direct cellular contact. The VIP-generated CD4~+ CD25~+ T_(reg) transfer suppression, inhibiting delayed-type hypersensitivity in the hosts, prevent graft-versus-host disease in irradiated host reconstituted with allogeneic bone marrow, and significantly ameliorate the clinical score in the collagen-induced arthritis model for rheumatoid arthritis and in the experimental autoimmune encephalomyelitis model for multiple sclerosis.
机译：CD4〜+ CD25〜+调节性T细胞（T_（reg））控制免疫应答对多种抗原，包括自我抗原，并且有几种模型支持CD4〜+ CD25〜+ T_的外周生产生的想法（REG ）来自CD4〜+ CD25〜 - T细胞。然而，关于内源性因素和控制CD4〜+ CD25〜+ T_（REG）的外周膨胀的机制知之甚少。我们发现免疫抑制神经肽血管活性肠肽（VIP）在体内诱导功能性Treg。将VIP与特异性抗原的给药与TCR转基因小鼠一起导致CD4〜+ CD25〜+，FoxP-3 /神经素1-表达T细胞的膨胀，这通过直接细胞接触抑制响应者T细胞增殖。的VIP生成的CD4 + CD25 + T_（REG）转移抑制，在主机抑制迟发型超敏反应，防止移植物抗宿主病在同种异体骨髓重建的辐照主机，显著改善在临床评分胶原诱导的类风湿性关节炎关节炎模型及实验性自身免疫性脑髓炎模型多发性硬化。

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