Functional roles of evolutionary conserved motifs and residues in vertebrate chemokine receptors

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Functional roles of evolutionary conserved motifs and residues in vertebrate chemokine receptors

机译：进化保守基序和残基在脊椎动物趋化因子受体中的功能作用

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Chemokinereceptorsregulatecellmigrationandhoming.Theybelongtotherhodopsin‐likefamilyofGPCRs.Theirancestorgenesemergedintheearlystagesofvertebrateevolution.Sincethen,thefamilyhasbeengreatlyexpandedthroughwholeandsegmentalgenomeduplicationevents.Duringevolution,manyaminoacidchangeshavebeenintroducedinindividualchemokinereceptors,butcertainmotifsandresiduesarehighlyconserved.Previously,weproposedanomenclaturesystemofthevertebratechemokinereceptorsbasedontheirevolutionaryhistoryandphylogeneticanalyses.Withtheuseofthisclassificationsystem,wearenowabletoconfidentlyassignthespeciesorthologsofvertebratechemokinereceptors.Here,wesystematicallyanalyzeconservedmotifsandresiduesofeachgroupoforthologouschemokinereceptorsthatmayplayimportantrolesintheirsignalingandbiologicfunctions.Ourpresentanalysismayprovideusefulinformationonhowindividualchemokinereceptorsareactivateduponligandbinding...

机译：Chemokinereceptorsregulatecellmigrationandhoming.Theybelongtotherhodopsin-likefamilyofGPCRs.Theirancestorgenesemergedintheearlystagesofvertebrateevolution.Sincethen，thefamilyhasbeengreatlyexpandedthroughwholeandsegmentalgenomeduplicationevents.Duringevolution，manyaminoacidchangeshavebeenintroducedinindividualchemokinereceptors，butcertainmotifsandresiduesarehighlyconserved.Previously，weproposedanomenclaturesystemofthevertebratechemokinereceptorsbasedontheirevolutionaryhistoryandphylogeneticanalyses.Withtheuseofthisclassificationsystem，wearenowabletoconfidentlyassignthespeciesorthologsofvertebratechemokinereceptors.Here，wesystematicallyanalyzeconservedmotifsandresiduesofeachgroupoforthologouschemokinereceptorsthatmayplayimportantrolesintheirsignalingandbiologicfunctions.Ourpresentanalysismayprovideusefulinformationonhowindividualchemokinereceptorsareactivateduponligandbinding ...

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2015年第1期|共9页
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Functional roles of evolutionary conserved motifs and residues in vertebrate chemokine receptors

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