...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Functional roles of evolutionary conserved motifs and residues in vertebrate chemokine receptors
【24h】

Functional roles of evolutionary conserved motifs and residues in vertebrate chemokine receptors

机译：进化保守基序和残基在脊椎动物趋化因子受体中的功能作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chemokine receptors regulate cell migration and homing. They belong to the rhodopsin-like family of GPCRs. Their ancestor genes emerged in the early stages of vertebrate evolution. Since then, the family has been greatly expanded through whole and segmental genome duplication events. During evolution, many amino acid changes have been introduced in individual chemokine receptors, but certain motifs and residues are highly conserved. Previously, we proposed a nomenclature system of the vertebrate chemokine receptors based on their evolutionary history and phylogenetic analyses. With the use of this classification system, we are now able to confidently assign the species orthologs of vertebrate chemokine receptors. Here, we systematically analyze conserved motifs and residues of each group of orthologous chemokine receptors that may play important roles in their signaling and biologic functions. Our present analysis may provide useful information on how individual chemokine receptors are activated upon ligand binding.
机译：趋化因子受体调节细胞迁移和归巢。它们属于视紫红质样的GPCR家族。他们的祖先基因出现在脊椎动物进化的早期。从那时起，该家族通过整个和分段基因组复制事件而大大扩展。在进化过程中，许多氨基酸的变化已被引入单个趋化因子受体，但某些基序和残基是高度保守的。以前，我们基于脊椎动物的趋化因子受体的进化历史和系统发育分析，提出了一个命名系统。使用此分类系统，我们现在可以放心地分配脊椎动物趋化因子受体的直系同源物种。在这里，我们系统地分析了每组直系趋化因子受体的保守基序和残基，它们可能在其信号传导和生物学功能中起重要作用。我们目前的分析可能提供有关配体结合后如何激活单个趋化因子受体的有用信息。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号