TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea

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TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea

机译：TLR9和TLR7 / 8激活诱导在小鼠角膜中形成角质沉淀物和巨噬细胞

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MacrophageadherencetotheinnercornealsurfaceandformationofMGCsinthestromaarecommonsignsofchronicinflammationfollowingcornealinfection.Todeterminewhethermacrophageadherence(knownclinicallyasKPs)andgiantcellformationwerespecifictoinnateimmuneactivationviaparticularTLRligands,macrophageactivationwasexaminedinamurinemodelofTLR‐mediatedcornealinflammation.ThecornealepitheliumwasdebridedandhighlypurifiedTLRligandsweretopicallyappliedoncetothecorneaofTLR7?/?,TLR9?/?,Cx3cr1gfp/+,CD11ceYFP,andIL‐4?/?mice.At1weekpost‐treatmentmacrophageactivationandphenotypewasevaluatedinthecornea.TreatmentwithTLR2,TLR3,TLR4,andTLR5ligandscausedanincreaseinthenumberofactivatedstromalmacrophagesinthecentralcorneaat1weekpost‐treatment.However,treatmentwithTLR9ligandCpG‐ODNandtheTLR7/8ligandR848/Resiquimodledtoanaccumulationofmacrophagesonthecornealendotheliumandformationofmultinucleatedgiantmacrophagesinthecornealstroma.Wesuggestthatgiantcellformation,whichisacharacteristicfeatureofgranulomaformationinmanytissues,maybeauniquefeatureofTLR9‐andTLR7/8‐mediatedmacrophageactivation...

机译：MacrophageadherencetotheinnercornealsurfaceandformationofMGCsinthestromaarecommonsignsofchronicinflammationfollowingcornealinfection.Todeterminewhethermacrophageadherence（knownclinicallyasKPs）andgiantcellformationwerespecifictoinnateimmuneactivationviaparticularTLRligands，macrophageactivationwasexaminedinamurinemodelofTLR-mediatedcornealinflammation.ThecornealepitheliumwasdebridedandhighlypurifiedTLRligandsweretopicallyappliedoncetothecorneaofTLR7？/ ?, TLR9？/ ?, Cx3cr1gfp / +，CD11ceYFP，和IL-4 /？？mice.At1weekpost-treatmentmacrophageactivationandphenotypewasevaluatedinthecornea.TreatmentwithTLR2，TLR3，TLR4，andTLR5ligandscausedanincreaseinthenumberofactivatedstromalmacrophagesinthecentralcorneaat1weekpost处理。但是，用TLR9ligandCpG-ODN和TLR7 / 8ligandR848 /进行必要的处理以使角膜内皮细胞中的巨噬细胞积累并在角膜基质中形成多核巨噬细胞。我们认为这种巨细胞形成是特征性的，肉芽肿形成的特征TLR9和TLR7 / 8介导的巨噬细胞活化的独特功能...

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2015年第1期|共8页
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1. TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea [J] . Chinnery Holly R., Leong Cheng Mee, Chen Weisan, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2015,第1期

机译：TLR9和TLR7 / 8激活诱导在小鼠角膜中形成角质沉淀物和巨噬细胞
2. TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer [J] . Butterfield John S. S., Biswas Moanaro, Shirley Jamie L., Human gene therapy methods. . 2019,第3期

机译：TLR9激活CpG-B ODN但不是TLR7激动剂触发抗体形成在肌肉基因转移中对因子IX
3. pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG [J] . Jing Wu, Shuang Li, Tete Li, Journal of immunology research. . 2019,第1期

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4. Ipomoea cornea Induced Enhanced Macrophage Activity (Phagocytosis and Peroxide Production) in Immunocompetent Rats [C] . I.M. Hueza, E.S.M. Fonseca, C.A. Paulino, International Symposium on Poisonous Plants . 2004

机译：IPOMOEA角膜诱导免疫活性大鼠增强的巨噬细胞活性（吞噬作用和过氧化物生产）
5. Long Noncoding RNA Signatures Induced by TLR7 and Type I IFN Signaling in Activated Human Plasmacytoid Dendritic Cells [D] . Joslyn, Rochelle Catherine 2018

机译：TLR7和I型IFN信号转导激活的人浆细胞样树突状细胞中诱导的长非编码RNA特征。
6. TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer [O] . John S.S. Butterfield, Moanaro Biswas, Jamie L. Shirley, -1

机译：TLR9激活CpG-B ODN但不是TLR7激动剂触发肌肉基因转移中因子IX的抗体形成。
7. TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea [O] . Chinnery HR, Leong CM, Chen W, 2015

机译：TLR9和TLR7 / 8激活诱导小鼠角膜中形成角质沉淀和巨噬细胞巨噬细胞
8. Macrophage Activation to Kill Leishmania Tropica: Characterization of P/J Mouse Macrophage Defects for Lymphokine-Induced Antimicrobial Activities Against Leishmania Tropica Amastigotes. [R] . Nacy, C. A., Meltzer, M. S., Fortier, A. H. 1984

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TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea

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