Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury

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Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury

机译：嗜碱性粒细胞对于脊髓半截损伤后的总体运动恢复是必不可少的

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Basophilsarethesmallestpopulationofgranulocytesfoundinthecirculation.Theyhavecrucialandnonredundantrolesinallergicdisorders,inprotectionfromparasiteinfections,inautoimmunity,andintheregulationoftype2immunity.Theysharephenotypicandfunctionalpropertieswithmastcells,whichexertsubstantialprotectiveeffectsaftertraumaticbraininjuryandspinalcordinjury,althoughtheyareconsideredoneofthemostproinflammatorycelltypesinthebody.Incontrast,theinvivofunctionsofbasophilsincentralnervoussystemtraumaarestillobscureandnotwellstudied.Inthisstudy,weshowthatbycomparingspinalcordinjuryinwildtypevs.basophil‐deficientMcpt8Cretransgenicmice,thelocomotorrecoveryisnotaffectedinmicedepletedinbasophils.Inaddition,nosubstantialdifferenceswereobservedinthelesionsizeandintheastrocyticandmacrophage/microgliareactionbetweenbothmousestrains.Hence,despitethemultiplepropertiessharedwithmastcells,thesedatashow,forthefirsttime,toourknowledge,thatbasophilsaredispensableforthefunctionalrecoveryprocessafterhemisectioninjurytothespinalcordinmice...

机译：Basophilsarethesmallestpopulationofgranulocytesfoundinthecirculation.Theyhavecrucialandnonredundantrolesinallergicdisorders，inprotectionfromparasiteinfections，inautoimmunity，andintheregulationoftype2immunity.Theysharephenotypicandfunctionalpropertieswithmastcells，whichexertsubstantialprotectiveeffectsaftertraumaticbraininjuryandspinalcordinjury，althoughtheyareconsideredoneofthemostproinflammatorycelltypesinthebody.Incontrast，theinvivofunctionsofbasophilsincentralnervoussystemtraumaarestillobscureandnotwellstudied.Inthisstudy，weshowthatbycomparingspinalcordinjuryinwildtypevs.basophil-deficientMcpt8Cretransgenicmice，thelocomotorrecoveryisnotaffectedinmicedepletedinbasophils.Inaddition，nosubstantialdifferenceswereobservedinthelesionsizeandintheastrocyticandmacrophage / microgliareactionbetweenbothmousestrains.Hence，despitethemultiplepropertiessharedwithmastcells，thesedatashow，forthefirsttime，toourknowledge，thatbasophilsaredispensableforthefunctionalrecoveryprocessafterhemisectioninjurytothe脊髓cordinmice ...

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2016年第4期|共4页
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1. Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury [J] . Geurts Nathalie, Vangansewinkel Tim, Lemmens Stefanie, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2016,第4期

机译：嗜碱性粒细胞对于脊髓半截损伤后的总体运动恢复是必不可少的
2. Histamine Promotes Locomotion Recovery After Spinal Cord Hemisection ivia/i Inhibiting Astrocytic Scar Formation [J] . Yan‐Yan Zhao, Yang Yuan, Ying Chen, CNS neuroscience & therapeutics. . 2015,第5期

机译：组胺通过抑制星形胶质细胞瘢痕形成促进脊髓半切后运动恢复
3. Synaptic plasticity modulates the spontaneous recovery of locomotion after spinal cord hemisection. [J] . Gulino R, Dimartino M, Casabona A, Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 2007,第1期

机译：脊髓半切后突触可塑性调节运动的自发恢复。
4. Functional Recovery Following Spinal Cord Hemisection Mediated by a Unique Polymer Scaffold Seeded with Neural Stem Cells [C] . Erin Eavik, Yang D.Teng, David Zurakowski, Materials Research Society Symposium . 2001

机译：脊髓上调后脊髓的功能恢复，由具有神经干细胞播种的独特的聚合物支架介导
5. A keratin biomaterial for treatment following spinal cord hemisection injury and investigation of secondary damage mechanisms. [D] . Fearing, Bailey V. 2014

机译：一种用于治疗脊髓半截损伤后的角蛋白生物材料，以及继发性损伤机制的研究。
6. Histamine Promotes Locomotion Recovery After Spinal Cord Hemisection via Inhibiting Astrocytic Scar Formation [O] . Yan‐Yan Zhao, Yang Yuan, Ying Chen, 2015

机译：组胺通过抑制星形胶质细胞瘢痕形成促进脊髓半切后的运动恢复
7. Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury [O] . Ansorena, E. (Eduardo), Berdt, P. (Pauline) de, Ucakar, B. (Bernard), 2013

机译：载有GDNF的可注射藻酸盐水凝胶可促进脊髓损伤半切模型中的功能恢复

Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury

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