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首页> 外文期刊>Neuroscience Research: The Official Journal of the Japan Neuroscience Society >Synaptic plasticity modulates the spontaneous recovery of locomotion after spinal cord hemisection.
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Synaptic plasticity modulates the spontaneous recovery of locomotion after spinal cord hemisection.

机译：脊髓半切后突触可塑性调节运动的自发恢复。

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摘要

Several evidences have demonstrated that adult mammals could achieve a wide range of spontaneous sensory-motor recovery after spinal cord injury by means of various forms of neuroplasticity. In this study we evaluated the possibility that after low-thoracic spinal cord hemisection in the adult rat, significant hindlimb locomotor recovery could occur, and that this recovery may be driven, at least in part, by mechanisms of synaptic plasticity. In order to address these issues, we measured the expression levels of synapsin-I and brain-derived neurotrophic factor by Western blotting, at various time points after hemisection and correlated them with the motor performance on a grid walk test. Regression analysis showed that the expression of synapsin-I was strongly correlated with the spontaneous recovery of hindlimb locomotion (R=0.78). Conversely, neither the expression levels of synapsin-I nor the locomotor recovery were associated with the expression of brain-derived neurotrophic factor. Overall resultsindicate that after spinal cord hemisection, substantial recovery of hindlimb locomotion could occur spontaneously, and that synaptic plasticity within spinal circuitries below the level of the lesion, could be an important mechanism involved in these processes.
机译：一些证据表明，成年哺乳动物可以通过各种形式的神经可塑性实现脊髓损伤后的多种自发感觉运动恢复。在这项研究中，我们评估了成年大鼠低胸脊髓半切后可能发生明显的后肢运动恢复的可能性，并且这种恢复可能至少部分地由突触可塑性机制驱动。为了解决这些问题，我们通过蛋白质印迹在半切后的不同时间点测量了突触蛋白-I和脑源性神经营养因子的表达水平，并通过网格行走测试将它们与运动表现相关联。回归分析表明突触素-I的表达与后肢运动的自发恢复密切相关（R = 0.78）。相反，突触素-I的表达水平和运动恢复均与脑源性神经营养因子的表达无关。总体结果表明，在脊髓半切后，后肢运动可能会自然恢复，并且在病变水平以下的脊髓回路内的突触可塑性可能是这些过程的重要机制。

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