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首页> 外文期刊>Journal of Medical Biochemistry >Expression Pattern of Long Non-coding RNA Growth Arrest-specific 5 in the Remission Induction Therapy in Childhood Acute Lymphoblastic Leukemia
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Expression Pattern of Long Non-coding RNA Growth Arrest-specific 5 in the Remission Induction Therapy in Childhood Acute Lymphoblastic Leukemia

机译：儿童急性淋巴细胞白血病白血病缓解诱导疗法中长非编码RNA长逮捕特异性5的表达模式。

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Summary Background Long non-coding RNA growth arrest-specific 5 ( GAS5 ) is deregulated in many cancers because of its role in cell growth arrest and apoptosis. Additionally, GAS5 interacts with glucocorticoid receptor, making it a potential pharmacotranscription marker of glucocorticoid (GC) therapy. In this study, we aimed at analysing GAS5 expression in the remission induction therapy phase of childhood acute lymphoblastic leukemia (ALL), in which GCs are mandatorily used, and to correlate it with therapy response. Methods GAS5 expression was measured in peripheral blood mononuclear cells taken from 29 childhood ALL patients at diagnosis, on day 15 and day 33 of remission induction therapy using RT-qPCR methodology. Results Our results have shown interindividual differences in GAS5 expression at all time points. For each ALL patient, GAS5 expression was higher on day 15 in comparison to its level at diagnosis (p&0.0005). On day 33, the level of GAS5 expression decreased in comparison with day 15 (p&0.0005), but it was still significantly higher than at diagnosis for the majority of patients (p=0.001). Patients whose number of blasts on day 8 was below 100 per μL of peripheral blood had a higher GAS5 expression at diagnosis (p=0.016), and lower ratio day 15/diagnosis (p=0.009). Conclusions Our results suggest that the expression level of GAS5 could be a potential marker of therapy response in remission induction therapy of childhood ALL.
机译：摘要背景长非编码RNA生长停滞特异性5（GAS5）由于在细胞生长停滞和细胞凋亡中的作用而在许多癌症中被失调。此外，GAS5与糖皮质激素受体相互作用，使其成为糖皮质激素（GC）治疗的潜在药物转录标记。在这项研究中，我们旨在分析GAS5在儿童急性淋巴细胞白血病（ALL）的缓解诱导治疗阶段的表达，其中强制使用GC，并将其与治疗反应相关联。方法采用RT-qPCR方法在缓解诱导治疗的第15天和第33天，对29例儿童ALL患者在诊断时的外周血单个核细胞中的GAS5表达进行测定。结果我们的结果显示了在所有时间点，GAS5表达的个体差异。对于每个ALL患者，与诊断时的水平相比，GAS5表达在第15天更高（p ＜0.0005）。在第33天，GAS5表达水平与第15天相比有所降低（p <0.0005），但对于大多数患者而言，仍显着高于诊断时的水平（p = 0.001）。在第8天的原始细胞数量低于每μL外周血100个的患者在诊断时具有较高的GAS5表达（p = 0.016），在第15天/诊断中的比率较低（p = 0.009）。结论我们的结果表明GAS5的表达水平可能是儿童ALL缓解诱导治疗中治疗反应的潜在标志。

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