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首页> 外文期刊>Journal of Medical Biochemistry >Usefulness of NT-proBNP in the Follow-Up of Patients after Myocardial Infarction
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Usefulness of NT-proBNP in the Follow-Up of Patients after Myocardial Infarction

机译：NT-proBNP在心肌梗死患者随访中的作用

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Summary Background Since serial analyses of NT-proBNP in patients with acute coronary syndromes have shown that levels measured during a chronic, later phase are a better predictor of prognosis and indicator of left ventricular function than the levels measured during an acute phase, we sought to assess the association of NT-proBNP, measured 6 months after acute myocardial infarction (AMI), with traditional risk factors, characteristics of in-hospital and early postinfarction course, as well as its prognostic value and optimal cut-points in the ensuing 1-year follow-up. Methods Fasting venous blood samples were drawn from 100 ambulatory patients and NT-proBNP concentrations in lithium-heparin plasma were determined using a one-step enzyme immunoassay based on the ?sandwich? principle on a Dimension RxL clinical chemistry system (DADE Behring-Siemens). Patients were followed-up for the next 1 year, for the occurrence of new cardiac events. Results Median (IQR) level of NT-proBNP was 521 (335–1095) pg/mL. Highest values were mostly associated with cardiac events during the first 6 months after AMI. Negative association with reperfusion therapy for index infarction confirmed its long-term beneficial effect. In the next one-year follow-up of stable patients, multivariate Cox regression analysis revealed the independent prognostic value of NT-proBNP for new-onset heart failure prediction (p=0.014), as well as for new coronary events prediction (p=0.035). Calculation of the AUCs revealed the optimal NT-proBNP cut-points of 800 pg/mL and 516 pg/mL, respectively. Conclusions NT-proBNP values 6 months after AMI are mainly associated with the characteristics of early infarction and postinfarction course and can predict new cardiac events in the next one-year follow-up.
机译：摘要背景由于对急性冠状动脉综合征患者进行NT-proBNP的系列分析表明，与急性期相比，在慢性，晚期阶段测得的水平更好地预测预后并指示左心室功能，因此我们寻求评估急性心肌梗死（AMI）后6个月测得的NT-proBNP与传统危险因素，院内和梗塞后早期病程的特征以及其预后价值和随后的最佳切入点的相关性1-一年的随访。方法从100名非卧床患者中抽取空腹静脉血，并采用基于“三明治”法的一步酶免疫法测定锂肝素血浆中的NT-proBNP浓度。 Dimension RxL临床化学系统（DADE Behring-Siemens）的原理。在接下来的1年中对患者进行随访，以了解是否发生了新的心脏事件。结果NT-proBNP的中位（IQR）水平为521（335-1095）pg / mL。最高值主要与AMI后的前6个月内的心脏事件有关。与再灌注疗法对指数梗死的负相关性证实了其长期有益效果。在接下来的一年对稳定患者的随访中，多因素Cox回归分析显示NT-proBNP对新发性心力衰竭的预测（p = 0.014）以及新的冠状动脉事件的预测（p = 0.035）。 AUC的计算显示最佳的NT-proBNP临界点分别为800 pg / mL和516 pg / mL。结论AMI后6个月的NT-proBNP值主要与早期梗死和梗塞后病程的特征有关，并且可以预测下一年的随访中的新心脏事件。

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