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首页> 外文期刊>Journal of Medical Biochemistry >The Importance of Haematological and Biochemical Findings in Patients with West Nile Virus Neuroinvasive Disease
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The Importance of Haematological and Biochemical Findings in Patients with West Nile Virus Neuroinvasive Disease

机译：西尼罗河病毒神经浸润性疾病患者血液学和生化检查结果的重要性

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Summary Background West Nile virus neuroinvasive disease (WNND) occurs in less than 1% of infected people. Leukocytosis with lymphocytopenia, mild anaemia, thrombocytopenia, elevated liver and muscle enzymes and hyponatremia are occasionally present in patients with WNND. Cerebrospinal fluid (CSF) findings resemble other viral neuroinfections. The purpose of this study is to pre sent some of the most important laboratory findings of our patients with WNND and to evaluate their correlation with fatal outcome. Methods The study included 161 patients with WNND. Their blood and CSF samples were cytobiochemically analysed and the obtained variables were then tested for predictive significance of the disease outcome, or used for differentiation between two clinical syndromes (encephalitis vs meningitis). Results West Nile encephalitis was present in 127 (78.9%) patients and West Nile meningitis was diagnosed in 34 (21.1%) cases. Leukocytosis was found in 45.9% patients. CRP level higher than 100 mg/L was registered only in those with encephalitis (p=0.020). CSF leukocyte count was 146±171 per microlitre, with slight lymphocytic predominance (mean 52%). Hypoglycorrhachia was registered in 9.3% of our patients with WNND. Twenty-eight (17.4%) patients died and all of them had encephalitis. Independent predictors of fatal outcome in WNND were serum CRP > 100 mg/L (p=0.011) and CSF proteins > 1 g/L (p=0.002). Conclusions WNND usually affects older males. Prolonged neutrophilic predominance in CSF can occasionally be present, as well as hypoglycorrhachia. Patients with encephalitis, high serum CRP and high CSF protein level have a higher risk of fatal outcome.
机译：背景技术西尼罗河病毒神经入侵疾病（WNND）发生在不到1％的感染人群中。 WNND患者偶尔会出现白细胞增多症伴淋巴细胞减少，轻度贫血，血小板减少，肝和肌肉酶升高以及低钠血症。脑脊液（CSF）的发现类似于其他病毒性神经感染。这项研究的目的是向我们的WNND患者提供一些最重要的实验室检查结果，并评估它们与致命结果的相关性。方法该研究纳入161例WNND患者。他们的血液和脑脊液样本进行了细胞生化分析，然后对获得的变量进行测试，以预测疾病结果的预测意义，或将其用于区分两种临床综合征（脑炎与脑膜炎）。结果127例（78.9％）患者患有西尼罗河脑炎，34例（21.1％）患者被诊断为西尼罗脑膜炎。在45.9％的患者中发现了白细胞增多症。仅在脑炎患者中记录到高于100 mg / L的CRP水平（p = 0.020）。每微升CSF白细胞计数为146±171，轻微的淋巴细胞优势（平均52％）。在我们的WNND患者中，有9.3％发生了低糖血症。二十八名患者（17.4％）死亡，全部患有脑炎。 WNND中致命结局的独立预测因子为血清CRP> 100 mg / L（p = 0.011）和CSF蛋白> 1 g / L（p = 0.002）。结论WNND通常会影响老年男性。脑脊液中长期嗜中性粒细胞占主导地位，以及低血糖。脑炎，高血清CRP和高CSF蛋白水平的患者致命危险更高。

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