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首页> 外文期刊>Journal of Medical Biochemistry >Could Lymphocyte Caspase-3 Activity Predict Atherosclerotic Plaque Vulnerability?
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Could Lymphocyte Caspase-3 Activity Predict Atherosclerotic Plaque Vulnerability?

机译：淋巴细胞Caspase-3活性能否预测动脉粥样硬化斑块的脆弱性？

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Could Lymphocyte Caspase-3 Activity Predict Atherosclerotic Plaque Vulnerability?Apoptotic cell death may play a critical role in a variety of cardiovascular diseases, especially in those developing on the basis of atherosclerosis. The goal of this study was to compare the activity of caspase-3 in different forms of ischemic heart disease and to correlate caspase-3 activity with inflammatory and lipid markers as well as risk factors. This enzyme activity was determined in peripheral blood mononuclear cells (PBMC) of 30 patients with stable angina pectoris (SAP), 27 with unstable angina (USAP), 39 with acute ST-elevation myocardial infarction (STEMI) and 27 healthy volunteers by a colorimetric commercially available ELISA method. In the SAP group caspase-3 activity was 0.093±0.036 μmol/mg protein, in patients with STEMI it was 0.110±0.062 μmol/mg protein, and both values were insignificantly higher in comparison with controls (0.092±0.022 μmol/mg protein). In PBMC of USAP patients caspase-3 activity (0.122±0.062 μmol/mg protein) was significantly higher (p<0.05) compared to the control group. In SAP patients caspase-3 activity showed a significant positive correlation with triglicerydes (p<0.05). Caspase-3 activity may be a valid parameter for assessing the atherosclerotic plaque activity, and a new target for therapeutic intervention.
机译：淋巴细胞Caspase-3活性能否预测动脉粥样硬化斑块的脆弱性？凋亡性细胞死亡可能在多种心血管疾病中发挥关键作用，尤其是在那些以动脉粥样硬化为基础发展的疾病中。这项研究的目的是比较不同形式的缺血性心脏病中caspase-3的活性，并将caspase-3的活性与炎症和脂质标记物以及危险因素相关联。通过比色法测定了30例稳定型心绞痛（SAP），27例不稳定型心绞痛（USAP），39例急性ST段抬高心肌梗死（STEMI）和27名健康志愿者的外周血单核细胞（PBMC）中的这种酶活性市售ELISA方法。在SAP组中，caspase-3活性为0.093±0.036μmol/ mg蛋白质，在STEMI患者中为0.110±0.062μmol/ mg蛋白质，与对照组（0.092±0.022μmol/ mg蛋白质）相比，这两个值均显着升高。与对照组相比，USAP患者的PBMC中的caspase-3活性（0.122±0.062μmol/ mg蛋白）显着更高（p <0.05）。在SAP患者中，caspase-3活性与triglicerydes呈显着正相关（p <0.05）。 Caspase-3活性可能是评估动脉粥样硬化斑块活性的有效参数，并且是治疗干预的新目标。

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