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首页> 外文期刊>Journal of medical bacteriology. >Frequency of Reduced Vancomycin Susceptibility among Clinical Staphylococcus aureus Isolated in Ahvaz Iran
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Frequency of Reduced Vancomycin Susceptibility among Clinical Staphylococcus aureus Isolated in Ahvaz Iran

机译：在伊朗阿瓦士分离的临床金黄色葡萄球菌中万古霉素敏感性降低的频率

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Introduction: One of the most important agents in hospital-acquired infections isStaphylococcus aureus. Treatment of methicillin-resistant S. aureus (MRSA) infections withdecreased susceptibility to vancomycin has recently been more difficult. The aim of this studywas to evaluate the possible presence of vancomycin intermediate S. aureus (VISA) andvancomycin- resistant S. aureus (VRSA) and also to determine the frequency of MRSA inclinical specimens.Methods: In this study, 195 S. aureus isolates were collected from the patients were examined.All of the isolates were identified using standard biochemical tests. Susceptibility of S. aureusisolates against 10 antibiotics was detected by disk diffusion method and was followed by E-testand vancomycin screen agar methods. Minimum inhibitory concentration (MIC) of vancomycinwas determined according to the CLSI guidelines. Also, detection of mecA gene was performedby PCR and finally, the results were compared.Results: All of the isolates were susceptible to vancomycin (i.e. MIC range of vancomycin wasbetween 0.25-2 μg/ml). Out of 195 S. aureus isolates, 99 isolates (50.8%) were resistant tomethicillin, and mecA gene was detected in 96 isolates. These results also showed that thehighest and lowest resistance rate of isolates was to penicillin (96.9%) and chloramphenicol(0%), respectively.Conclusion: Our findings showed that vancomycin can still be used as a valuable drug fortreatment of S. aureus infections in our region. However, periodic evaluation of vancomycinMIC of S. aureus isolates is critical for monitoring MRSA and preventing the spread of VISA orVRSA among patients.
机译：简介：医院获得性感染中最重要的药物之一是金黄色葡萄球菌。最近，对耐甲氧西林的金黄色葡萄球菌（MRSA）感染的万古霉素敏感性降低。这项研究的目的是评估可能存在的万古霉素金黄色葡萄球菌（VISA）和耐万古霉素的金黄色葡萄球菌（VRSA），并确定MRSA临床标本的频率。方法：本研究中，分离出195个金黄色葡萄球菌。从患者身上收集了标本进行了检查。所有分离株均使用标准生化检验进行了鉴定。用圆盘扩散法检测金黄色葡萄球菌对10种抗生素的敏感性，然后用E检验和万古霉素琼脂筛选法检测。根据CLSI指南确定万古霉素的最小抑菌浓度（MIC）。结果：所有分离株均对万古霉素敏感（即万古霉素的MIC范围在0.25-2μg/ ml之间）。在195株金黄色葡萄球菌中，有99株（50.8％）对甲氧西林耐药，在96株中检测到mecA基因。这些结果还表明，分离株的最高耐药率和最低耐药率分别是对青霉素（96.9％）和氯霉素（0％）。结论：我们的发现表明，万古霉素仍可作为治疗金黄色葡萄球菌感染的有价值的药物。我们的地区。但是，定期评估金黄色葡萄球菌分离株的万古霉素MIC对于监测MRSA和防止VISA或VRSA在患者中扩散至关重要。

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