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首页> 外文期刊>Journal of medical bacteriology. >Evaluation of Antimicrobial Activity of Probiotic Lactobacillus Strains against Growth and Urease Activity of Proteus spp.
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Evaluation of Antimicrobial Activity of Probiotic Lactobacillus Strains against Growth and Urease Activity of Proteus spp.

机译：益生乳杆菌菌株对变形杆菌属的生长和脲酶活性的抗菌活性评估。

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Background: Nowadays, the use of probiotic bacteria for the prevention and treatment of urinary tract infections is growing. Lactobacillus, as probiotic bacterial genus, is well known for its benefits for the human health.Methods: The effects of partially purified antimicrobial compounds (bacteriocins and biosurfactants) of Lactobacillus strains was assessed and their capacity to in vitro inhibit growth and urease production of various strains of Proteus spp, was studied. Inhibition of the urease production of Proteus spp. at sub-MIC levels was screened using spectrophotometry method. Results: Results revealed that semi-purified bacteriocins of L. acidophilus and L. plantarum showed a greater inhibitory activity on the bacterial urease, compared to biosurfactants of L. rhamnosus, L. casei and L. fermentum (P < 0.05).Conclusion: It can be concluded that bacteriocins may affect Proteus pathogenesis by inhibition of the bacterial urease activity and therefore eliminate the stone formation by these bacteria.
机译：背景：如今，益生菌在预防和治疗尿路感染中的应用正在增长。乳酸菌作为益生菌属细菌，对人类健康有益。方法：评估了乳酸菌菌株的部分纯化的抗菌化合物（细菌素和生物表面活性剂）的作用，并评估了它们在体外抑制各种生长和脲酶生产的能力。对变形杆菌属的菌株进行了研究。抑制变形杆菌属的脲酶生产。使用分光光度法筛选亚MIC水平的蛋白。结果：结果表明，与鼠李糖乳杆菌，干酪乳杆菌和发酵乳杆菌的生物表面活性剂相比，半纯化的嗜酸乳杆菌和植物乳杆菌的细菌素对细菌脲酶表现出更大的抑制活性（P <0.05）。可以得出结论，细菌素可通过抑制细菌尿素酶的活性来影响变形杆菌的发病机理，从而消除这些细菌的结石形成。

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