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首页> 外文期刊>Journal of Medical Biochemistry >Muscle-Invasive Transitional Cell Carcinoma of the Urinary Bladder is Associated with Down-Regulated CPP32 Expression and BCL-2 Positivity
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Muscle-Invasive Transitional Cell Carcinoma of the Urinary Bladder is Associated with Down-Regulated CPP32 Expression and BCL-2 Positivity

机译：膀胱膀胱的肌肉浸润性移行细胞癌与下调的CPP32表达和BCL-2阳性相关。

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Muscle-Invasive Transitional Cell Carcinoma of the Urinary Bladder is Associated with Down-Regulated CPP32 Expression and BCL-2 PositivityThe objective was to get insight into the role of executive apoptotic enzyme caspase 3 (CPP32) and regulatory antiapoptotic protein Bcl-2 in the malignant phenotype of TCC. Samples were obtained from 84 TCC patients, who underwent transurethral resection, partial or radical cystectomy. Staging showed a superficial growth pattern in 41 patient, while other 43 showed invasive characteristics. Expression of CPP32 and Bcl-2 was determined by immunocytochemistry. Levels of expression were correlated with tumor stage and grade. Expression of CPP32 was positive in 80% of TCC patients. Low-, medium- and high positive status were observed in 18%, 24% and 38% of patients, respectively. There was a signifficant difference in the CPP32 expression between groups with superficial and invasive TCC tumors (p = 0.032), with frequency of CPP32 negative samples being higher and CPP32 high-positive samples being lower in patients with muscle-invasive tumors. Significant association was also found between CPP32 expression and tumor stage (p = 0.043). The positive rate of Bcl-2 protein expression was 48%. There was a statisticaly signifficant difference in the rate of Bcl-2 positivity between superficial and invasive TCC (p = 0.005), with frequency of Bcl-2 positive patients being higher in muscle-invasive TCC. Significant association was also found between Bcl-2 expression and both tumor grade (p=0.032) and stage (p=0.007). Muscle invasive TCC of the urinary bladder is associated with down-regulated expression of CPP32 and Bcl-2 positivity. Down-regulation of CPP32 and up-regulated Bcl-2 might, at least partially, play a role in the development of invasive characteristics of TCC.
机译：膀胱膀胱侵袭性移行细胞癌与CPP32表达下调和BCL-2阳性相关目的是深入了解执行性凋亡酶半胱氨酸蛋白酶3（CPP32）和抗凋亡调控蛋白Bcl-2在恶性肿瘤中的作用TCC的表型。样本取自84名接受经尿道切除，部分或根治性膀胱切除术的TCC患者。分期在41例患者中显示出表面生长模式，而其他43例显示出侵入性特征。通过免疫细胞化学确定CPP32和Bcl-2的表达。表达水平与肿瘤的分期和等级相关。 80％的TCC患者中CPP32的表达为阳性。在18％，24％和38％的患者中分别观察到低，中和高阳性状态。在患有表面浸润性和浸润性TCC肿瘤的组之间，CPP32表达存在显着差异（p = 0.032），在患有肌肉浸润性肿瘤的患者中，CPP32阴性样本的频率较高，而CPP32高阳性样本的频率较低。在CPP32表达与肿瘤分期之间也发现了显着关联（p = 0.043）。 Bcl-2蛋白表达的阳性率为48％。浅表性和浸润性TCC之间的Bcl-2阳性率存在统计学上的显着差异（p = 0.005），而Bcl-2阳性患者在肌肉浸润性TCC中的发生率更高。在Bcl-2表达与肿瘤分级（p = 0.032）和分期（p = 0.007）之间也发现了显着的关联。膀胱的肌肉浸润性TCC与CPP32和Bcl-2阳性表达的下调有关。 CPP32的下调和Bcl-2的上调可能至少部分地在TCC侵袭性特征的发展中起作用。

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