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首页> 外文期刊>Journal of Medical Biochemistry >Pathophysiological importance of nitric oxide in coronary heart disease / Patofiziolo?ki zna?aj azot-monoksida u koronarnoj bolesti srca
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Pathophysiological importance of nitric oxide in coronary heart disease / Patofiziolo?ki zna?aj azot-monoksida u koronarnoj bolesti srca

机译：一氧化氮在冠心病中的病理生理重要性

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Summary Nitric oxide (NO) is produced by many cells in the body; however, its production by vascular endothelium is particularly important in the regulation of blood flow. Vascular actions of NO include the following: direct vasodilation, indirect vasodilation by inhibiting the vasoconstrictor influences, anti-thrombotic, anti-inflammatory and anti-proliferative effects. Due to its importance in vascular function, abnormal production of NO, occurring in different diseases can adversely affect blood flow and other vascular functions. It has been suggested that alterations in NO generation are a critical cause of injury in the ischemic heart. A biologic link between the endothelial damage and atherosclerotic coronary arterial disease has been presumably related to de - creased arterial bioavailability of NO through the increased leucocyte and platelet adhesions, vasoconstriction and smooth muscle cell proliferation. However, the precise me - chanism of the impaired NO generation is not known, and there is a considerable controversy regarding whether myo - cardial ischemia results in increased or decreased NO for - mation. Asymmetric dimethylarginine (ADMA) is a natural, com petitive inhibitor, and one of the primary factors controlling the nitric oxide production. ADMA was found to be elevated and closely correlated with the impaired vasodilator function in conditions associated with the endothelial dysfunction, such as hypercholesterolemia, hypertension, insulin resistance and type 2 diabetes, and renal failure. But ADMA also seems to be involved in myocardial ischemia, since its plasma levels predict future coronary events in patients with the elevated cardiovascular risk. It has been recently reported that the elevated plasma ADMA concentrations in the acute coronary events are an independent cardiovascular risk factor.
机译：小结人体中的许多细胞都会产生一氧化氮（NO）。然而，其通过血管内皮产生的物质在调节血流中特别重要。 NO的血管作用包括：直接血管舒张，通过抑制血管收缩剂影响而进行的间接血管舒张，抗血栓形成，抗炎和抗增殖作用。由于其在血管功能中的重要性，在不同疾病中发生的NO异常产生会不利地影响血流和其他血管功能。已经提出，NO生成的改变是缺血性心脏损伤的关键原因。内皮损伤与动脉粥样硬化性冠状动脉疾病之间的生物学联系据推测与NO通过增加白细胞和血小板粘附，血管收缩和平滑肌细胞增殖而降低的生物利用度有关。但是，尚不清楚NO生成受损的确切机制，关于心肌缺血导致NO形成增加还是减少，存在很大争议。不对称二甲基精氨酸（ADMA）是一种天然的竞争性抑制剂，是控制一氧化氮生成的主要因素之一。在与内皮功能障碍相关的疾病中，例如高胆固醇血症，高血压，胰岛素抵抗和2型糖尿病以及肾功能衰竭，发现ADMA升高且与血管舒张功能受损密切相关。但是ADMA似乎也参与了心肌缺血，因为它的血浆水平可以预测心血管风险升高的患者未来的冠脉事件。最近有报道说，急性冠脉事件中血浆ADMA浓度升高是独立的心血管危险因素。

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