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首页> 外文期刊>Journal of Medical Biochemistry >Antiepileptic Drugs Affect Protein, Lipid and DNA Oxidative Damage and Antioxidant Defense in Patients with Epilepsy
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Antiepileptic Drugs Affect Protein, Lipid and DNA Oxidative Damage and Antioxidant Defense in Patients with Epilepsy

机译：抗癫痫药影响癫痫患者的蛋白质，脂质和DNA氧化损伤和抗氧化防御

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Summary Background: To get more insight into the effects of the most widely used antiepileptic drugs (AEDs) on the prooxidant/ antioxidant balance in epilepsy, a comparative analysis of the byproducts of oxidative damage and antioxidant de fense mechanisms was performed in patients with epilepsy treated with lamotrigine, carbamazepine and valproic acid.Methods: Byproducts of oxidative damage to proteins (reactive carbonyl derivatives, RCD and protein thiol groups, PSH), lipids (urinary isoprostanes, 8-epi-PGF2a) and DNA (urinary 8-hydroxy-2’-deoxyguanosine, 8-OHdG), as well as the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX) were measured in 60 patients with newly diagnosed seizure (at illness onset and after 6 months of treatment with lamotrigine, carbamazepine or valproic acid) and in 20 healthy controls.Results: In patients with epilepsy, RCD, urinary 8-epi-PGF2a and 8-OHdG, together with SOD and GPX activities were significantly increased, while P-SH were only slightly decreased. After 6 months of treatment with AEDs, a decrease was observed in RCD, urinary 8-epi-PGF2a and 8-OHdG to values slightly higher or similar to the control, while P-SH remained unchanged. A decrease was also observed in SOD and GPX activities, although they remained significantly in creased compared to controls.Conclusions: The results of this study have shown that treatments with lamotrigine, carbamazepine and valproic acid affect the prooxidant/antioxidant balance in patients with epilepsy.
机译：摘要背景：为了更深入地了解最广泛使用的抗癫痫药（AED）对癫痫患者中前氧化剂/抗氧化剂平衡的影响，对癫痫患者的氧化损伤副产物和抗氧化剂防御机制进行了比较分析。方法：蛋白质（反应性羰基衍生物，RCD和蛋白质硫醇基，PSH），脂质（尿异前列腺素，8-epi-PGF2a）和DNA（尿8-羟基-2）氧化损伤的副产物在60例新确诊的癫痫发作患者中（疾病发作时和拉莫三嗪治疗6个月后），测定了'-脱氧鸟苷，8-OHdG）以及抗氧化酶超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPX）的活性，结果：在癫痫患者中，RCD，尿中的8-epi-PGF2a和8-OHdG以及SOD和GPX活性显着增加。缓解，而P-SH仅略有下降。在用AED治疗6个月后，观察到RCD，尿中的8-epi-PGF2a和8-OHdG降低至略高于或近似于对照的值，而P-SH保持不变。结论：本研究结果表明，拉莫三嗪，卡马西平和丙戊酸治疗会影响癫痫患者的抗氧化/抗氧化平衡，尽管如此，SOD和GPX的活性也有所降低。

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