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首页> 外文期刊>Journal of Medical Sciences >Vaginal Colonization of Group B Streptococci During Late Pregnancy in Southeast of Iran: Incidence, Serotype Distribution and Susceptibility to Antibiotics
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Vaginal Colonization of Group B Streptococci During Late Pregnancy in Southeast of Iran: Incidence, Serotype Distribution and Susceptibility to Antibiotics

机译：伊朗东南部妊娠后期B群链球菌的阴道定植：发生率，血清型分布和对抗生素的敏感性

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The objective of present study was to determine reliable data on vaginal carriage, serotype distribution and antibacterial susceptibility of Streptococcus agalactiae , Group B streptococcus (GBS) in pregnant women in southeast of Iran. Vaginal swab cultures for GBS were obtained from 602 pregnant women at childbirth. Susceptibility of the isolates to penicillin, ampicillin, clindamycin and erythromycin were determined by standard agar dilution method. Isolates were classified according to their capsular polysaccharide types. GBS was isolated from 55 pregnant women (9.1%). All isolates were sensitive to penicillin and ampicillin [Minimum Inhibitory concentration (MIC) range of 0.03-16 μg mL-1 and ≤ 0.03-1 μg mL-1, respectively). Erythromycin and clindamycin resistance were seen in 10.9% (MIC range ≤ 0.03-16 μg mL-1) and 25.4% (MIC range ≤ 0.03-32 μg mL-1) of the isolates, respectively. Serotype III (41.8%), Ib (25.45%) and II were the most frequently isolated serotypes (14.54%). Group IV was not detected and 14.54% of the isolates were non type-able. No correlation was found between GBS colonization and demographic factors of age, parity, history of abortion or ruptured membrane and vaginal signs or symptoms. In conclusion the rate of GBS colonization is low in this area, but serotype III, which is mostly involved in invasive disease is the predominant serotype. Routine maternal screening should be performed to prevent group B streptococcal disease in neonates in this district. Susceptibility to the isolates to clindamycin and erythromycin should be checked in the penicillin-allergic patients, to avoid treatment failure.
机译：本研究的目的是确定伊朗东南部孕妇的无乳链球菌B组链球菌（GBS）的阴道运输，血清型分布和抗菌药敏性的可靠数据。 GBS的阴道拭子培养是从602名分娩的孕妇中获得的。通过标准琼脂稀释法测定分离株对青霉素，氨苄青霉素，克林霉素和红霉素的敏感性。分离物根据其荚膜多糖类型分类。 GBS分离自55名孕妇（9.1％）。所有分离株均对青霉素和氨苄西林敏感[最小抑菌浓度（MIC）分别为0.03-16μgmL -1 和≤0.03-1μgmL -1 。红霉素和克林霉素耐药性分别为10.9％（MIC范围≤0.03-16μgmL -1 ）和25.4％（MIC范围≤0.03-32μgmL -1 ）分离株。血清型III（41.8％），Ib（25.45％）和II是最常见的血清型（14.54％）。未检测到IV组，且有14.54％的分离株无法分型。在GBS定植与年龄，胎次，流产或胎膜破裂史以及阴道征象或症状的人口统计学因素之间未发现相关性。总之，该地区GBS的定殖率很低，但是主要与侵袭性疾病有关的III型血清型是主要的血清型。应进行常规产妇筛查，以预防该地区新生儿的B组链球菌疾病。对青霉素过敏的患者应检查其对克林霉素和红霉素的敏感性，以免治疗失败。

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