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首页> 外文期刊>Journal of Medical Cases >Prolonged Bradycardia Induced by Bevacizumab-Associated Infusion Reaction in Advanced Metastatic Colon Cancer
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Prolonged Bradycardia Induced by Bevacizumab-Associated Infusion Reaction in Advanced Metastatic Colon Cancer

机译：贝伐单抗相关输注反应在晚期转移性结肠癌中引起的心动过缓。

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A 71-year-old man complaining of bilateral leg edema and general fatigue was admitted to the hospital and diagnosed as advanced sigmoid colon cancer with multiple liver and lung metastasis. The 5-FU/leucovorin/oxaliplatin (FOLFOX)/bevacizumab was started as a first-line therapy. In the second course of FOLFOX/bevacizumab, just after finishing infusion of bevacizumab, he felt severe thrill with chill and got fever (maximum of 38.1 °C). Since the symptom was diagnosed as an infusion reaction induced by bevacizumab, treatment with steroid and histamine antagonist was performed. His symptom disappeared soon after the treatment; however, his heart rate came lower below 50/minute 5 hours after the infusion reaction (his heart rate was routinely around 60/minute). The 12-lead electrocardiogram showed sinus bradycardia. The bradycardia (30 - 49/minute) continues at least 60 hours and spontaneously recovered. Literature search of PubMed showed just two papers implying the relation between bevacizumab and bradycardia. This case suggested that bradycardia induced by bevacizumab-associated infusion reaction should be carefully followed up and might be observed with admission if necessary.J Med Cases. 2015;6(5):194-197doi: http://dx.doi.org/10.14740/jmc2066w
机译：一名主治双侧腿浮肿和全身疲乏的71岁男子入院，被诊断为晚期乙状结肠癌并伴有多处肝和肺转移。 5-FU /亚叶酸钙/奥沙利铂（FOLFOX）/贝伐单抗开始作为一线治疗。在FOLFOX /贝伐单抗的第二疗程中，刚完成贝伐单抗的输注后，他感到剧烈的冷颤和发烧（最高38.1°C）。由于症状被诊断为贝伐单抗诱导的输注反应，因此进行了类固醇和组胺拮抗剂的治疗。治疗后不久，他的症状消失了。但是，输液反应后5小时，他的心率降低到低于50 /分钟（他的心率通常约为60 /分钟）。 12导联心电图显示窦性心动过缓。心动过缓（30-49 /分钟）持续至少60小时并自发恢复。对PubMed的文献搜索仅显示了两篇暗示贝伐单抗与心动过缓之间关系的论文。该病例提示应仔细随访由贝伐单抗相关的输注反应引起的心动过缓，必要时可观察到这种情况。JMed病例。 2015; 6（5）：194-197doi：http://dx.doi.org/10.14740/jmc2066w

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