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首页> 外文期刊>Journal of Medical Cases >A Case of Severe Fever With Thrombocytopenia Syndrome Accompanied by Self-Limiting Severe Proteinuria That Inversely Correlated With the Platelet Count
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A Case of Severe Fever With Thrombocytopenia Syndrome Accompanied by Self-Limiting Severe Proteinuria That Inversely Correlated With the Platelet Count

机译：与血小板计数成反比的自我限制的严重蛋白尿伴发血小板减少综合征的重度发热一例

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We herein present a case of a 68-year-old man who was referred to our hospital for a tick bite accompanied by fever and general malaise. He exhibited typical clinical symptoms such as abdominal pain, diarrhea, and vomiting during hospitalization. A laboratory examination showed progressive thrombocytopenia and leukopenia during the early part of hospitalization. A definite diagnosis of severe fever with thrombocytopenia syndrome (SFTS) was made by a reverse transcription polymerase chain reaction (RT-PCR) from his blood sample in the Tokushima Prefectural Public Health Institute. Proteinuria is generally detected in more than half of patients with SFTS. In the present case, the clinical course showed a clear inverse correlation between self-limiting severe proteinuria and the platelet count during hospitalization. Although it is not currently clear how immunological interactions among the virus, platelets, and immunoglobulins affect the glomerulus or cause proteinuria, our results may contribute to elucidating the pathogenic mechanism of SFTS-associated glomerulonephritis. To the best of our knowledge, this case report is the first to show an inverse correlation between proteinuria and the platelet count in a patient with SFTS.J Med Cases. 2016;7(10):435-440doi: http://dx.doi.org/10.14740/jmc2642w
机译：我们在此介绍了一个68岁男子的案例，该男子因a虫叮咬伴发烧和全身不适而被转诊到我们医院。他在住院期间表现出典型的临床症状，例如腹痛，腹泻和呕吐。实验室检查显示，住院初期有进行性血小板减少症和白细胞减少症。通过从德岛县公共卫生研究所的血液样本中进行逆转录聚合酶链反应（RT-PCR），可以明确诊断患有严重血小板减少症（SFTS）的发烧。通常在一半以上的SFTS患者中检测到蛋白尿。在本例中，临床过程显示自限性严重蛋白尿与住院期间血小板计数之间存在明显的负相关。尽管目前尚不清楚病毒，血小板和免疫球蛋白之间的免疫相互作用如何影响肾小球或引起蛋白尿，但我们的结果可能有助于阐明SFTS相关性肾小球肾炎的致病机制。据我们所知，该病例报告首次显示了患有SFTS的患者的蛋白尿与血小板计数呈负相关。 2016; 7（10）：435-440doi：http://dx.doi.org/10.14740/jmc2642w

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