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首页> 外文期刊>Journal of Medical Genetics and Genomics >Effect of paternal age on aneuploidy rates in first trimester pregnancy loss
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Effect of paternal age on aneuploidy rates in first trimester pregnancy loss

机译：父本年龄对孕早期妊娠流产非整倍体率的影响

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A retrospective cohort analysis of patients undergoing IVF cycles at an academic IVF center was performed to test the hypothesis that male age may influence aneuploidy rates in first trimester pregnancy losses. All patients had a first trimester pregnancy loss followed by evacuation of the pregnancy and karyotyping of the abortus. Couples undergoing anonymous donor oocyte ART cycles (n = 50) and 23 couples with female age less than 30 years undergoing autologous oocyte ART cycles were included. The oocyte age was less than 30 in both groups; thereby allowing the focus to be on the reproductive potential of the aging male. The main outcome measure was the effect of paternal age on aneuploidy rate. No increase in aneuploidy rate was noted with increasing paternal age (50 years = 25.0%). Although there was a significant difference in the male partner age between oocyte recipients and young patients using autologous oocytes (33.7?? 7.6 vs. 41.5?? 6.8) (p <0.0001), no difference in aneuploidy rate was observed between these groups (30.0% vs. 26.1%) (p=0.66; RR=0.93; 95% CI (0.68-1.27)). While controlling for female age by using donor oocyte patients, the study’s preliminary data support that paternal age does not affect aneuploidy rates.
机译：在学术IVF中心对经历IVF周期的患者进行了回顾性队列分析，以检验以下假设：男性年龄可能影响孕早期妊娠丢失的非整倍体率。所有患者在妊娠早期均流产，随后撤出妊娠并进行流产核型分析。包括进行匿名供体卵母细胞ART周期（n = 50）的夫妇和女性年龄小于30岁的23对夫妇进行自体卵母细胞ART周期。两组的卵母细胞年龄均小于30。从而使焦点集中在衰老男性的生殖潜力上。主要结局指标是父亲年龄对非整倍性率的影响。随着父亲年龄的增加（50岁= 25.0％），非整倍体率没有增加。尽管卵母细胞接受者和使用自体卵母细胞的年轻患者之间的男性伴侣年龄有显着差异（33.7-7.6 vs. 41.5-6.8）（p <0.0001），但两组之间的非整倍体率没有差异（30.0） ％vs. 26.1％）（p = 0.66; RR = 0.93; 95％CI（0.68-1.27））。该研究的初步数据在通过使用供体卵母细胞患者控制女性年龄的同时，也证明父亲的年龄不会影响非整倍体率。

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