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首页> 外文期刊>Journal of Medical Sciences >Subacute Toxicity Studies of 4-hydroxy Nitrobenzene Isolated from Streptomyces Species
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Subacute Toxicity Studies of 4-hydroxy Nitrobenzene Isolated from Streptomyces Species

机译：链霉菌属物种的4-羟基硝基苯的亚急性毒性研究

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The sub acute toxicity study of an antimicrobial compound, 4-hydroxy nitrobenzene isolated from a Streptomyces species was carried out on long Evan?s rats. The compound, 4-hydroxy nitrobenzene (300μg) was administered daily for 14 days and its effect on body weight, hematological and biochemical parameters of blood was investigated. There was no significant difference between weight gain in rats, receiving compound and control (121±5.10 vs 115±7.2g, respectively). There were no significant changes detected in hematology (red blood cells, 5.63±0.23 vs 4.97±0.17; white blood cells, 12575±170.78 vs 10950±238; platelet, 312500 ± 9574 vs 31000±21602 (cells ml-1)x106; hemoglobin, 13.25±0.3 vs 13.27 ±0.36%, for experimental and control rats, respectively) or blood biochemistry (serum glutamic oxaloacetic transaminase, 11.5±1.29 vs 11.75±1.25IU L-1, serum glutamate pyruvate transaminase, 8.25±1.26 vs 7.25±1.5IU L-1, serum alkaline phosphatase 41.25 ±1.89 vs 44.25 ± 3.3IU L-1. Uric acid, 7.05±0.129 vs 7.3± 0.22; urea, 42.25 ± 1.708 vs 41.5 ± 2.64; creatinine, 0.85±0.05 vs 1.07±0.188mg dL-1, for experimental and control rats, respectively). Therefore, the compound, 4-hydroxy nitrobenzene (300μg day-1) over 14 days, had no toxic effects on rats.
机译：从长链霉菌属物种中分离出的抗菌化合物4-羟基硝基苯的亚急性毒性研究。化合物4-羟基硝基苯（300μg）每天给药14天，研究其对体重，血液血液学和生化指标的影响。接受化合物和对照组的大鼠体重增加之间无显着差异（分别为121±5.10和115±7.2g）。血液学没有发现显着变化（红细胞，5.63±0.23 vs.4.97±0.17;白细胞，12575±170.78 vs 10950±238;血小板，312500±9574 vs 31000±21602（细胞ml -1 ）x10 6 ;血红蛋白，分别为实验大鼠和对照大鼠，分别为13.25±0.3和13.27±0.36％）或血液生化（血清谷氨酸草酰乙酸转氨酶，分别为11.5±1.29和11.75±1.25） IU L -1 ，血清谷氨酸丙酮酸转氨酶，8.25±1.26 vs 7.25±1.5IU L -1 ，血清碱性磷酸酶41.25±1.89 vs 44.25±3.3IU L -1 。尿酸7.05±0.129 vs 7.3±0.22;尿素42.25±1.708 vs 41.5±2.64;肌酐0.85±0.05 vs 1.07±0.188mg dL -1 分别用于实验和对照大鼠）。因此，该化合物4-羟基硝基苯（300μgday -1 ）在14天内对大鼠没有毒性作用。

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