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首页> 外文期刊>Journal of Medical Sciences >Waist-to-Hip Ratio, Body Mass Index and Sex Hormone Levels Associated with Breast Cancer Risk in Premenopausal Caucasian Women
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Waist-to-Hip Ratio, Body Mass Index and Sex Hormone Levels Associated with Breast Cancer Risk in Premenopausal Caucasian Women

机译：绝经前白人女性的腰臀比，体重指数和性激素水平与乳腺癌风险的关系

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Obese women and women with upper body fat distribution have been shown to have a hormonal profile associated with increased risk of breast cancer . This study examines the relationships between obesity and body fat distribution, and sex hormones. Data from 47 healthy nulliparous premenopausal Caucasian women were collected cross-sectionally. Eight were obese and 39 non-obese. Thirteen had normal body fat (NBF) while 34 lower body fat (LBF) phenotypes. The concentrations of serum estrone, estrone sulfate, estradiol, free estradiol (Free E2), %Free E2, androstenedione, testosterone, free testosterone (Free T), %Free T, prolactin and sex hormone-binding globulin (SHBG) levels were determined in the mid-follicular phase. In multivariate regression analyses controlling for age, age at menarche and body mass index (BMI), a 0.1 unit increase in waist-to-hip circumference ratio (WHR) towards the normal range decreased %Free T by 18% (p=0.03), %Free E2 by 15% (p=0.07) and increased SHBG by 36% (p=0.07). In similar analyses controlling for WHR, a unit increase in BMI increased %Free E2 by 0.25%(p=0.04), %Free T by 0.23% (p=0.07), and decreased that SHBG by 0.52% (p=0.07). Multivariate comparison showed SHBG levels to be higher by 39% (p=0.02) and %Free E2 lower by 13% (p=0.07) in NBF compared to LBF phenotype women. Multivariate comparison between obese and non-obese women, however, showed SHBG levels to be lower by 24% (p=0.04), and %Free E2 higher by 18% (p=0.04) in obese women. Results suggest that obesity and increasing BMI are associated with a serum sex hormone profile that increases breast cancer risk; however, increasing WHR towards the normal range is not associated with a high risk sex hormone profile. WHR in the normal range appears to be associated with a sex hormone profile that is more protective compared to the lower range.
机译：肥胖妇女和上身脂肪分布的妇女已被证明具有与乳腺癌风险增加相关的激素分布。这项研究检查了肥胖与体内脂肪分布以及性激素之间的关系。横断面收集了47名健康的绝经前绝经前白人妇女的数据。 8人肥胖，39人不肥胖。 13例具有正常体脂（NBF），而34例下体脂肪（LBF）表型。确定血清雌酮，硫酸雌酮，雌二醇，游离雌二醇（游离E2），％游离E2，雄烯二酮，睾丸激素，游离睾丸激素（游离T），％游离T，催乳素和性激素结合球蛋白（SHBG）的浓度在卵泡中期。在控制年龄，初潮年龄和体重指数（BMI）的多元回归分析中，腰臀围比（WHR）朝正常范围增加0.1个单位会使游离T降低18％（p = 0.03） ，游离E2的百分比增加15％（p = 0.07），SHBG增加36％（p = 0.07）。在控制WHR的类似分析中，BMI的单位增加使游离E2％增加0.25％（p = 0.04），游离T％0.23％（p = 0.07），并使SHBG降低0.52％（p = 0.07）。多变量比较显示，与LBF表型女性相比，NBF中的SHBG水平高39％（p = 0.02），游离E2％低13％（p = 0.07）。肥胖和非肥胖女性之间的多变量比较显示，肥胖女性的SHBG水平降低了24％（p = 0.04），游离E2％升高了18％（p = 0.04）。结果表明，肥胖和BMI升高与血清性激素水平相关，从而增加患乳腺癌的风险。但是，将WHR升高至正常范围与高危性激素水平无关。正常范围内的WHR似乎与性激素概况有关，与较低范围相比，该激素更具保护性。

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