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首页> 外文期刊>Journal of Medical Sciences >C-terminal Propeptide of Type-I Procollagen as a Possible Biochemical Marker for Preclinical Detection of Cardiac Disease in Chronic Renal Failure
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C-terminal Propeptide of Type-I Procollagen as a Possible Biochemical Marker for Preclinical Detection of Cardiac Disease in Chronic Renal Failure

机译：I型胶原蛋白的C末端前体可能是临床上慢性肾脏衰竭的心脏疾病临床检测的生化标记

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The aim of present research was to investigate the possible role of C-terminal propeptide of type-I procollagenas a biochemical marker for early preclinical detection of Left Ventricular (LV) dysfunction in children with CRF. The study included 25 children with CRF undergoing hemodialysis for at least six months. Their age ranged from 8-16 years. Patients were receiving erythropoietin and anti-hypertensive medications. Serum was withdrawn from patients during the time interval between two dialytic sessions for estimation of CICP. The systolic and diastolic functions of the LV were investigated by echocardiography. Mean level of CICP was significantly higher in patients than in controls. Echocardiographic findings revealed significantly higher mean LV mass index, interventricular septal thickness, LV posterior wall thickness and E/A ratio in patients versus controls. Left atrial and ventricular diameters were significantly higher, whereas EF and FS% were lower in patients than controls. There were positive correlations between CICP levels and LVMI, IVST, LVPWT and E/A ratio. CICP correlated with the duration of illness, blood pressure , BUN and creatinine. We conclude that CICP levels are strongly correlated with the early changes that occur in the heart of CRF children, namely LV hypertrophy and diastolic filling abnormalities. CICP could be used as a reliable preclinical serological marker for detection of these changes.
机译：本研究的目的是调查I型前胶原的C末端前肽的可能作用，该生化标志物是早期临床前检测CRF儿童左心室（LV）功能障碍的生化标记。该研究包括25名接受血液透析至少六个月的CRF儿童。他们的年龄从8-16岁不等。患者正在接受促红细胞生成素和抗高血压药物。在两次透析之间的时间间隔内，从患者身上抽出血清以估计CICP。通过超声心动图检查左室的收缩和舒张功能。患者的CICP平均水平显着高于对照组。超声心动图检查发现，与对照组相比，平均左心室质量指数，室间隔厚度，左心室后壁厚度和E / A比明显更高。患者的左心房和心室直径显着较高，而患者的EF和FS％低于对照组。 CICP水平与LVMI，IVST，LVPWT和E / A比呈正相关。 CICP与疾病持续时间，血压，BUN和肌酐相关。我们得出的结论是，CICP水平与CRF儿童心脏发生的早期变化密切相关，即LV肥大和舒张期充盈异常。 CICP可用作检测这些变化的可靠的临床前血清学标记。

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