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首页> 外文期刊>Journal of Medical Sciences >Antinociceptive Effect of (α2-Adrenoceptor Agonist) Dexmedetomidine vs Meperidine, Topically, after Laparoscopic Gynecologic Surgery
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Antinociceptive Effect of (α2-Adrenoceptor Agonist) Dexmedetomidine vs Meperidine, Topically, after Laparoscopic Gynecologic Surgery

机译：腹腔镜妇科手术后局部使用（α 2 -肾上腺素受体激动剂）右美托咪定与哌替啶的镇痛作用

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摘要

This prospective double blinded study compared the analgesic effect of intraperitoneal dexmedetomidine or meperidine with bupivacaine to intraperitoneal bupivacaine alone in laparoscopic gynecologic surgery. Sixty female patients undergone elective laparoscopic gynecologic surgery given a standardized general anesthesia were randomly allocated into one of three equal sized groups; Group B: intraperitoneal 50 mL bupivacaine 0.25%, Group B+M: intraperitoneal 50 mL bupivacaine 0.25%+1 mg kg-1 meperidine and Group B+D: intraperitoneal 50 mL bupivacaine 0.25%+1 ??g kg-1 dexmedetomidine. The following parameters were evaluated: (1) Time to first request of analgesia, (2) The incidence and severity of postoperative shoulder pain for 24 h postoperatively, (3): The amount of postoperative PCA morphine for 24 h postoperatively. Times to first request of analgesia was significantly short in group B compared to the other 2 groups (p -1) or dexmedetomidine (1 ??g kg-1) in combination with bupivacaine 0.25% in female patients undergoing laparoscopic gynecologic surgery significantly decreases the postoperative analgesic requirements and decreased the incidence of shoulder pain compared to intraperitoneal bupivacaine 0.25% alone.
机译：这项前瞻性双盲研究比较了腹腔镜妇科手术中腹膜内右美托咪定或哌替卡因联合布比卡因的镇痛效果。将60例接受了常规全身麻醉的择期腹腔镜妇科手术的女性患者随机分为三组，每组相等。 B组：腹膜内50mL布比卡因0.25％，B组+ M：腹膜内50mL布比卡因0.25％+ 1 mg kg -1 哌替啶，B + D组：腹膜内50mL布比卡因0.25％+ 1？ ？g kg -1 右美托咪定。评价以下参数：（1）首次镇痛的时间，（2）术后24 h术后肩痛的发生率和严重程度，（3）：术后24 h术后PCA吗啡的量。与其他两组（p -1 ）或右美托咪定（1 ?? g kg -1 ）联合布比卡因0.25相比，B组首次镇痛的时间明显缩短相较于腹膜内注射布比卡因0.25％，接受腹腔镜妇科手术的女性患者中的5％显着降低了术后镇痛要求并降低了肩痛的发生率。

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