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首页> 外文期刊>Journal of medical bacteriology. >Effect of Amniotic Membrane Combined with Ciprofloxacin in Curing the Primary Stages of Pseudomonal Keratitis
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Effect of Amniotic Membrane Combined with Ciprofloxacin in Curing the Primary Stages of Pseudomonal Keratitis

机译：羊膜联合环丙沙星治疗假性角膜炎初期的作用

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Background: Keratitis caused by Pseudomonas aeruginosa is often resulted in severe corneal ulcers and perforation, which leads to losses of vision. Human amniotic membrane (HAM) forms the inner wall of the membranous sac which surrounds and protects the embryo during gestation. The purpose of this study was to evaluate the effectiveness of the amniotic membrane's healing in rabbits with pseudomonas keratitis.Methods: In total 14 rabbits divided in 2 groups of: 1 as Control and 2 as experimental amniotic membrane combined with ciprofloxacin. A 0.05 ml suspension of Pseudomonas aeruginosa ATCC 27853 was injected into rabbit’s corneal stroma, with no interference in control group. In the second group, the amniotic membrane in pieces of 1.5 × 1.5 cm transplanted to the entire corneal surface by eight interrupted 10.0 nylon sutures. In the first day ciprofloxacin drop was injected to the second group every 30 minutes and through second to seventh days every 2 hours. The results of perforation in cornea and the amount of infiltration were registered.Results: The results showed that amniotic membrane transplantation (AMT) + ciprofloxacin group had 0% perforation and the control group 85.6%. Average infiltrations were 5 mm in AMT + ciprofloxacin groups and 23.75 mm in control.Conclusion: The use of amniotic membrane with ciprofloxacin was effective in prevention of cornea perforation and controlling the process of pseudomonal keratitis remission. The improvement of inflammation rapidly happened in ciprofloxacin + AMT group.
机译：背景：由铜绿假单胞菌引起的角膜炎通常导致严重的角膜溃疡和穿孔，从而导致视力丧失。人羊膜（HAM）形成了膜囊的内壁，该膜囊在妊娠期间围绕并保护了胚胎。本研究的目的是评估假单胞菌性角膜炎兔羊膜的愈合效果。方法：共14只兔，分为两组：1只作为对照组，另2只作为实验羊膜联合环丙沙星。将0.05 ml铜绿假单胞菌ATCC 27853悬浮液注射到兔的角膜基质中，而对照组没有干扰。在第二组中，通过八根中断的10.0尼龙缝线将1.5×1.5 cm的羊膜碎片移植到整个角膜表面。在第一天，每30分钟将环丙沙星滴剂注射到第二组，并每2小时注射第二至第七天。结果：结果表明，羊膜移植（AMT）+环丙沙星组的穿孔率为0％，对照组为85.6％。 AMT +环丙沙星组的平均浸润为5 mm，对照组为23.75 mm。结论：羊膜与环丙沙星一起使用可有效预防角膜穿孔并控制假性角膜炎缓解。环丙沙星+ AMT组的炎症迅速改善。

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