• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of medical bacteriology. >Helicobacter pylori hrgA, A Novel Discriminatory Biomarker for Duodenal Ulcer Patients
【24h】

Helicobacter pylori hrgA, A Novel Discriminatory Biomarker for Duodenal Ulcer Patients

机译：幽门螺杆菌hrgA，十二指肠溃疡患者的新型歧视性生物标志物

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Helicobacter pylori is a major human gastric for various gastro duodenal diseases.A number of putative virulence factors such as dupA, homB, tnpA have been described. To date,none were found to be significantly associated with specific H. pylori-related diseases (e.g. gastric cancer and duodenal ulcer).Methods: the primary aim of this study was to test the H. pylori hrgA genotype isolated from 253 Iranian symptomatic patients to investigate possible association with clinical outcomes. The positive culture results were confirmed by glmM (genetic control for H. pylori) PCR assay.Results: The results showed hrgA gene was detected in 44/253 strains (17.3%). Prevalence of the hrgA gene was relatively high in strains isolated from duodenal ulcer patients (P=0.0063; Odd ratio: 3.54; CI 95%: 1.42-8.77).Conclusions: In contrast our findings showed that the prevalence of hrgA in our control group (gastritis patients) was 22.7% (P>0.05). Conclusively, hrgA gene is a good candidate as a discriminatory biomarker for patients with duodenal ulcer
机译：背景：幽门螺杆菌是人类各种胃十二指肠疾病的主要胃病，已描述了许多假定的毒力因子，如dupA，homB，tnpA。迄今为止，没有发现与特定的幽门螺杆菌相关疾病（例如胃癌和十二指肠溃疡）显着相关。方法：本研究的主要目的是测试从253名伊朗有症状患者中分离出的幽门螺杆菌hrgA基因型。调查可能与临床结果的关系。阳性培养结果通过glmM（幽门螺杆菌的遗传对照）PCR检测得到证实。结果：结果显示，在44/253株（17.3％）中检测到hrgA基因。从十二指肠溃疡患者中分离出的菌株中hrgA基因的患病率较高（P = 0.0063;奇数比：3.54; CI 95％：1.42-8.77）。 （胃炎患者）为22.7％（P> 0.05）。结论是，hrgA基因是十二指肠溃疡患者的有选择性的生物标志物

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号