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首页> 外文期刊>Journal of Medical Case Reports >Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report
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Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report

机译：甲状腺和乳头状乳头状癌为碰撞肿瘤伴淋巴结转移：一例报道

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Introduction Papillary thyroid carcinoma and medullary thyroid carcinoma are two different thyroid neoplasia. The simultaneous occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma as a collison tumor with metastases from both lesions in the regional lymph nodes is a rare phenomenon. Case presentation A 32-year-old Iranian man presented with a fixed anterior neck mass. Ultrasonography revealed two separate thyroid nodules as well as a suspicious neck mass that appeared to be a metastatic lesion. The results of thyroid function tests were normal, but the preoperative calcitonin serum value was elevated. Our patient underwent a total thyroidectomy with neck exploration. Two separate and ill-defined solid lesions grossly in the right lobe were noticed. Histological and immunohistochemical studies of these lesions suggested the presence of medullary thyroid carcinoma and papillary thyroid carcinoma. The lymph nodes isolated from a neck dissection specimen showed metastases from both lesions. Conclusions The concomitant occurrence of papillary thyroid carcinoma and medullary thyroid carcinoma and the exact diagnosis of this uncommon event are important. The treatment strategy should be reconsidered in such cases, and genetic screening to exclude multiple endocrine neoplasia 2 syndromes should be performed. For papillary thyroid carcinoma, radioiodine therapy and thyroid-stimulating hormone suppressive therapy are performed. However, the treatment of medullary thyroid carcinoma is mostly radical surgery with no effective adjuvant therapy.
机译：引言甲状腺乳头状癌和甲状腺髓样癌是两种不同的甲状腺肿瘤。甲状腺髓样癌和乳头状甲状腺癌同时发生，是一种Collison肿瘤，并从区域淋巴结的两个病变处转移，这是罕见的现象。病例介绍一名32岁的伊朗男子出现固定的前颈部肿块。超声检查显示两个单独的甲状腺结节以及可疑的颈部肿块，看起来是转移性病变。甲状腺功能检查结果正常，但术前降钙素血清值升高。我们的患者接受了颈部探查的全甲状腺切除术。注意到右叶上有两个明显分开的实体病灶。这些病变的组织学和免疫组化研究表明存在甲状腺髓样癌和甲状腺乳头状癌。从颈部解剖标本中分离出的淋巴结均显示出两种病变的转移。结论甲状腺乳头状癌和甲状腺髓样癌的同时发生以及对这一罕见事件的准确诊断具有重要意义。在这种情况下，应重新考虑治疗策略，并应进行基因筛查以排除多发性内分泌肿瘤2综合征。对于甲状腺乳头状癌，需要进行放射性碘疗法和甲状腺刺激激素抑制疗法。但是，甲状腺髓样癌的治疗大多是根治性手术，没有有效的辅助疗法。

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