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首页> 外文期刊>Journal of Medical Sciences >Chlorine Level as a Predictive Factor for Oxaliplatin-induced Peripheral Neuropathy
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Chlorine Level as a Predictive Factor for Oxaliplatin-induced Peripheral Neuropathy

机译：氯水平作为奥沙利铂诱导的周围神经病变的预测因素

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Peripheral neuropathy is a major adverse event associated with oxaliplatin-based chemotherapy and is a major dose-limiting adverse event in clinical practice. However, some patients treated with oxaliplatin may show no or minimal peripheral neuropathy. These differences are still poorly understood. This study was carried out as a retrospective analysis of 77 patient?s data that had been treated with oxaliplatin-based regimens at the South Dhaka Medical Center between January 2005 and June 2010. Among them 51 patients data were selected and factor analysis was performed. The serum Chlorine (Cl) level at baseline was significantly higher in patients with a high frequency of peripheral neuropathy (106; range 104-107 vs. 104; range 101-104 mEq L-1, p = 0.02). Principal component analysis showed the variables Cl, body mass index, status of liver metastasis and status of lymph node metastasis were related to the incidence of peripheral neuropathy. Discriminant analysis showed the model had predicted 72.5% of peripheral neuropathy. An understanding of the patient?s characteristics could be useful for preventing or predicting oxaliplatin-induced peripheral neuropathy.
机译：周围神经病变是与基于奥沙利铂的化学疗法相关的主要不良事件，并且是临床实践中的主要剂量限制性不良事件。但是，一些用奥沙利铂治疗的患者可能没有或只有很少的周围神经病变。这些差异仍然知之甚少。这项研究是对2005年1月至2010年6月间在南达卡医学中心接受奥沙利铂治疗的77例患者数据的回顾性分析。选择了51例患者数据并进行了因子分析。周围神经病变频繁的患者，基线时的血清氯水平明显升高（106; 104-107相对于104; 101-104 mEq L -1 ，p = 0.02）。主成分分析表明，变量Cl，体重指数，肝转移状况和淋巴结转移状况与周围神经病变的发生有关。判别分析显示该模型预测了72.5％的周围神经病变。了解患者的特征可能有助于预防或预测奥沙利铂引起的周围神经病变。

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