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首页> 外文期刊>Journal of Medical Sciences >Antioxidant Effects of Aqueous Extract of Sweet Potato and Ascorbic Acid on Paracetamol Induced Damage
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Antioxidant Effects of Aqueous Extract of Sweet Potato and Ascorbic Acid on Paracetamol Induced Damage

机译：红薯水提取物和抗坏血酸对扑热息痛致损伤的抗氧化作用

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The antioxidant effects of aqueous extract of sweet potato (Ipomoea batata) and ascorbic acid on paracetamol induced damage in liver and kidney were investigated in female rats by monitoring the enzymatic and non-enzymatic antioxidant profiles as well as lipid peroxidation and serum enzymes activities. The rats were given freshly prepared aqueous extract of sweet potato (100 mg kg-1 body weight) or ascorbic acid (100 mg kg-1 body weight) orally for 4 weeks. These rats were also given paracetamol (4 g kg-1 body weight) orally for 2 days at the last week of treatment. Another group of rats were either given extract (100 mg kg-1 body weight. daily, orally, for 4 weeks) or ascorbic acid (100 mg kg-1 body weight. daily, orally, for 4 weeks) or paracetamol (4 g kg-1 body weight for 2 days) or distilled water. The results show that the level of lipid peroxides in the liver and kidney and serum enzymes GOT and GPT activities were significantly decreased in extract and ascorbic acid pretreated rats when compared to control (p ascorbic acid pretreated rats compared to control. Paracetamol significantly reduced the activities of these enzymes in liver but the reduction in SOD activity was not significant in the kidney when compared to control. There were significant increase in reduced Glutathione (GSH) in both organs in ascorbic acid pretreated rat but the increase were not significant in extract pretreated rats. Paracetamol significantly decrease GSH level in the liver when compared to control. The study revealed that sweet potato extract and ascorbic acid have a potential to prevent oxidative damage induced by acute dose of paracetamol in both the liver and the kidney.
机译：通过监测酶促和非酶促抗氧化谱以及脂质过氧化和血清酶活性，研究了雌性大鼠甘薯水提取物和抗坏血酸对扑热息痛引起的肝和肾损害的抗氧化作用。给大鼠口服新鲜制备的甘薯水提取物（体重100 mg kg -1 ）或抗坏血酸（体重100 mg kg -1 ）4周。在治疗的最后一周，还给这些大鼠口服对乙酰氨基酚（4 g kg -1 体重），持续2天。另一组大鼠接受提取物（每天100 mg kg -1 体重，口服，持续4周）或抗坏血酸（100 mg kg -1 体重）每天口服4周）或扑热息痛（体重4 g kg -1 2天）或蒸馏水。结果表明，与对照组相比，提取物和抗坏血酸预处理的大鼠肝脏和肾脏中的脂质过氧化物水平以及血清酶GOT和GPT活性均显着降低（对抗坏血酸预处理的大鼠与对照组相比。扑热息痛显着降低了活性这些酶在肝脏中的含量，但与对照组相比，肾脏中的SOD活性降低不明显;抗坏血酸预处理的大鼠的两个器官中谷胱甘肽（GSH）的减少均显着增加，而提取物预处理的大鼠则无明显变化与扑热息痛相比，扑热息痛可显着降低肝脏中的谷胱甘肽水平;研究表明，番薯提取物和抗坏血酸具有预防急性剂量扑热息痛在肝脏和肾脏中引起的氧化损伤的潜力。

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