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首页> 外文期刊>Journal of Medical Sciences >Comparative Free Radical Scavenging and Analgesic Activity of Ethanolic Leaves and Stem Extracts of Solanum nigrum
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Comparative Free Radical Scavenging and Analgesic Activity of Ethanolic Leaves and Stem Extracts of Solanum nigrum

机译：龙葵叶片和龙葵茎提取物的自由基清除和镇痛活性比较

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摘要

In the present investigation a comparative analysis of the Free radical scavenging potential and analgesic activity of the Ethanolic Leaf (ELS) and stem extracts (ESS) of Solanum nigrum was performed. The extracts were evaluated for its DPPH and hydroxyl free radical s scavenging effect and inhibitory potential on protein carbonyl formation. Total phenolic and flavonoid content of the extracts were also determined by a colorimetric method. The ethanolic extract s of Solanum nigrum were evaluated for its peripheral analgesic activity by Acetic-acid induced writhing response and central analgesic activity by Tail flicking method and Hot plate method in mice. Both the plant extracts scavenged the free radical s in a dose dependent manner. However the scavenging effect was more pronounced in ELS extract when comparable to ESS extract. Both the extract possessed considerable quantity of phenols and flavonoids. In Tail flicking and Hot plate methods the ELS extract of Solanum nigrum showed higher mean basal latency time when comparable to ESS extract suggesting its central analgesic activity. Similarly in Acetic acid induced writhing response the ELS extract exhibited a significant inhibition of writhing 53.28% when comparable to ESS which exhibited an inhibition of 46.53%. The positive control Diclofenac sodium showed 70.66% of writhing inhibition. The analgesic activity of the plants extracts is probably due to its free radical scavenging activity.
机译：在本研究中，对茄子的无烟叶（ELS）和茎提取物（ESS）的自由基清除潜力和镇痛活性进行了比较分析。评估提取物的DPPH和清除羟基自由基的作用以及对蛋白质羰基形成的抑制潜力。提取物中总酚和类黄酮含量也通过比色法测定。通过醋酸诱导的扭体反应评价龙葵乙醇提取物的外周镇痛活性，并通过甩尾法和热板法评价小鼠中枢镇痛活性。两种植物提取物均以剂量依赖性方式清除自由基。但是，当与ESS提取物相当时，清除效果在ELS提取物中更为明显。两种提取物均具有大量的酚和类黄酮。在甩尾法和热板法中，龙葵的ELS提取物与ESS提取物相比显示出更高的平均基础潜伏时间，表明其中央镇痛活性。类似地，在乙酸诱导的扭曲反应中，当与ESS表现出46.53％的ESS相当时，ELS提取物表现出显着的扭曲抑制53.28％。阳性对照双氯芬酸钠显示出70.66％的扭曲抑制。植物提取物的镇痛活性可能是由于其自由基清除活性。

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