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首页> 外文期刊>Journal of Medical Sciences >Spermatotoxicity in Animal Models Exposed to Fragrance Components
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Spermatotoxicity in Animal Models Exposed to Fragrance Components

机译：暴露于香气成分的动物模型中的精子毒性

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Various commonly-used products have been reported to contain chemicals that could disrupt estrogen and testosterone hormone. As trade secrets, these chemicals are generally listed as fragrance to mask individual identity. In this study, the reproductive implications of two commonly used perfumes (designated as F1 and F2) in Nigeria were carried out. Sixty adult male wistar rats (12-13 weeks old) were randomly divided into four groups (A-F) of ten rats each. Group A and B rats were exposed to 5 mL kg-1 b.wt. of normal saline for 56 days and 112 days, respectively via whole body inhalation. Group C and D rats were exposed to 5 mL kg-1 b.wt. of a fragrance product designated as F1 for a period of 56 days and 112 days, respectively while Group E and Group F rats were exposed to 5 mL kg-1 b.wt. of a designated fragrance product F2 for a period of 56 days and 112 days, respectively. The results obtained from this study showed a significant (p0.005) when compared to values of the control group A and B. Based on the spermiographic evaluation from this study, fragrance materials could have an adverse effect on spermatozoa of the intact male wistar rats .
机译：据报道，各种常用产品中含有会破坏雌激素和睾丸激素的化学物质。作为商业秘密，这些化学药品通常被列为香料，以掩盖个人身份。在这项研究中，进行了尼日利亚两种常用香水（分别称为F1和F2）的生殖影响。将60只成年雄性wistar大鼠（12-13周大）随机分为四组（A-F），每组十只。 A和B组大鼠均暴露于5 mL kg -1 b.wt。通过全身吸入分别服用56天和112天的生理盐水。 C组和D组大鼠均暴露于5 mL kg -1 b.wt。在E组和F组大鼠分别暴露于5 mL kg -1 b.wt.的条件下，分别将指定为F1的香精产品分别历时56天和112天。指定香料产品F2的使用期限分别为56天和112天。与对照组A和对照组B的值相比，此研究的结果显示出显着的（p0.005）。根据这项研究的精子学评估，香料可能会对完整的雄性Wistar大鼠的精子产生不利影响。

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