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首页> 外文期刊>Journal of Medical Sciences >Effect of Two Controller Medications with Inhaled Corticosteroid in Mild to Moderate Persistent Asthma Patients
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Effect of Two Controller Medications with Inhaled Corticosteroid in Mild to Moderate Persistent Asthma Patients

机译：两种吸入性糖皮质激素控制药物对轻度至中度持续性哮喘患者的影响

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Asthma is an inflammatory disease characterized by recurrent episodes of breathlessness and wheezing. Though inhaled corticosteroids play a vital role in the treatment of asthma, it alone or with long acting beta agonist cannot control asthma symptoms in most of the patients. The present study aims to assess the two controller medications in the form of oral tablets with inhaled corticosteroid combination in controlling forced expiratory volume in one second (FEV1) in mild to moderate persistent asthma patients. A total of 108 patients with mild to moderate asthma were enrolled in this randomized controlled study from the pulmonary medicine department of a tertiary care hospital. Patients were randomized into two groups viz., Group 1 (n = 54) and Group 2 (n = 54). Group 1 patients received Montelukast and Group 2 patients received Doxofylline. Both the groups received Budesonide inhaler. Pulmonary function test was assessed at the baseline and on follow up days. No significant difference was observed with respect to socioeconomic and educational status of patients between the groups. Significant (p1 after 120 days treatment was observed with both Montelukast and Doxofylline treated groups. There is no statistically significance between the groups. No major adverse events were found during the study period. The study concluded that both controller medications helped in improving lung function.
机译：哮喘是一种炎症性疾病，其特征是反复出现呼吸困难和喘息。尽管吸入皮质类固醇激素在哮喘的治疗中起着至关重要的作用，但单独或与长效β受体激动剂结合使用并不能控制大多数患者的哮喘症状。本研究旨在评估轻度至中度持续性哮喘患者口服糖皮质激素组合口服片剂形式的两种控制药物，以控制一秒钟内的呼气量（FEV 1 ）。这项来自三级医院肺科的随机对照研究共纳入108名轻度至中度哮喘患者。将患者随机分为两组，即组1（n = 54）和组2（n = 54）。第1组患者接受了孟鲁司特治疗，第2组患者接受了多索茶碱治疗。两组均接受布地奈德吸入器。在基线和随访日评估肺功能测试。两组之间在患者的社会经济和教育状况方面没有观察到显着差异。孟鲁司特和多索茶碱治疗组在120天治疗后均观察到显着性（p1 ）。两组之间无统计学意义。在研究期间未发现重大不良事件。研究得出结论，两种控制药物均有助于改善肺功能。

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