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首页> 外文期刊>Journal of Medical Sciences >Protective Effect of Silymarin and Vitamine-E in Hepatotoxicity Induced by Valporic Acid in Albino Rats
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Protective Effect of Silymarin and Vitamine-E in Hepatotoxicity Induced by Valporic Acid in Albino Rats

机译：水飞蓟素和维生素E对丙戊酸引起的白化大鼠肝毒性的保护作用

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Administration of valporic acid, the most common medication prescribed against epilepsy produces many metabolic and morphological aberrations in liver due to the fact that liver is the main detoxifying site for these antiepileptic drugs. This experimental work was done for study of the prophylactic role of silymarin and vitamin E in hepatotoxic induced by valporic acid in albino rats. Fifty adult male albino rats weighting 150-200 g were divided into five equal groups, one control and the other four for the drugs. Group I control group is subdivided into two subgroups (IA, IB). Group II ingested valporic acid, group III ingested valporic acid+silymarin, group IV ingested valporic acid+vitamine E and finally group V ingested valporic acid+both drugs, the ingestion was done through orogastric tube for four week. After four weeks biochemical studies (ALT, AST and total bilirubin) were done for all rats in all groups, then the rats were sacrificed and histopathological studies were done for their livers. Bio chemical analysis revealed significant increased in AST, ALT and total bilirubin in the group II, III, IV and V in comparison with control groups and revealed significant decrease in the group III, IV and V in comparison with group II. Histopathological examination of the group II revealed necro-inflammatory foci with infiltration of the hepatic lobules with inflammatory cells and inflammation in the portal tract. Histopathological examination of the liver section of group III, IV and V showed mild necrosis and inflammation in hepatic lobules and showed mild inflammation in the portal tract. The liver is highly affected by ingestion of valporic acid. However, ingestion of silymarin and/or vitamine E that is naturally occurring antioxidants can decrease this harmful effect of these drugs on the liver. Therefore, the patient on chronic use of valporic acid must use silymarin and/or vitamin E to protect their livers.
机译：由于肝是这些抗癫痫药的主要排毒部位，因此，抗癫痫病最常用的药物丙戊酸的给药会在肝脏中产生许多代谢和形态异常。这项实验工作是为了研究水飞蓟素和维生素E在丙戊酸大鼠中由丙戊酸引起的肝毒性的预防作用。将五十只体重为150-200 g的成年雄性白化病大鼠分为五个相等的组，一个为对照组，另四个为药物。第一组对照组分为两个亚组（IA，IB）。第II组摄取戊酸，III组摄取戊酸+水飞蓟素，IV组摄取戊酸+维生素E，最后V组摄取戊酸+两种药物，均通过胃胃管摄取4周。对所有组的所有大鼠进行四周的生化研究（ALT，AST和总胆红素）后，处死大鼠并对其肝脏进行组织病理学研究。生化分析显示，与对照组相比，第二，第三，第四和第五组的AST，ALT和总胆红素显着增加，与第二组相比，第三，第四和第五组的AST，ALT和总胆红素显着降低。对第二组的组织病理学检查显示，坏死性炎症灶伴有肝小叶浸润，伴有炎症细胞和门道炎症。对III，IV和V组的肝脏切片的组织病理学检查显示肝小叶轻度坏死和炎症，并在门脉中显示轻度炎症。丙戊酸的摄入会严重影响肝脏。但是，摄入天然存在的抗氧化剂水飞蓟素和/或维生素E可以减少这些药物对肝脏的有害作用。因此，长期使用丙戊酸的患者必须使用水飞蓟素和/或维生素E来保护肝脏。

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