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首页> 外文期刊>Journal of Medical Sciences >Screening 469 Escherichia coli Isolates Form South East of Iran for Tellurite Resistance Phenotype
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Screening 469 Escherichia coli Isolates Form South East of Iran for Tellurite Resistance Phenotype

机译：筛选伊朗东南部地区的469个大肠杆菌分离物的亚碲酸盐抗性表型

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Minimum Inhibitory Concentration (MIC) of tellurite was determined for 469 samples of Escherichia coli isolated from clinical samples in human ( urinary tract infection , normal fecal flora), or poultry skin using standard agar dilution method. About half of the isolates (47.1%) had MIC of ≤1 μg mL-1 after 24 h of incubation at 35°C. Many of the bacteria that were cultured with low concentrations of potassium tellurite, ≤ 5 μg mL-1, overcome the toxicity of this heavy metal when they were re-incubated for the next 24 h. The MIC for these isolates was increased, so that the difference between the MIC after 24 and 48 h of incubation became significant (p≤0.0026). In medium containing ≥10 μg mL-1 of potassium tellurite, the bacteria formed typical black colonies. No statistically significant difference was found between the MIC of bacteria that where isolated from human, but higher rate of resistance was found for the Poultry skin samples and 25% of these isolates had MIC of ≥160 μg mL-1. Although for nearly half of the isolates potassium tellurite was toxic at low concentration (≤1 μg mL-1), higher MIC was observed for the rest of isolates (10-400 μg mL-1) and is an indication of the widespread resistance to potassium tellurite in E. coli in this region.
机译：使用标准琼脂稀释法，对从人（尿路感染，正常粪便菌群）或家禽皮肤的临床样品中分离出的469个大肠杆菌样品，测定了亚碲酸盐的最低抑制浓度（MIC）。在35°C孵育24小时后，大约一半的分离株（47.1％）的MIC≤1μgmL -1 。在低浓度的亚碲酸钾（≤5μgmL -1 ）中培养的许多细菌在接下来的24小时重新温育时都克服了这种重金属的毒性。这些分离株的MIC增加，因此孵育24和48小时后MIC之间的差异变得显着（p≤0.0026）。在含有≥10μgmL -1 的亚碲酸钾的培养基中，细菌形成典型的黑色菌落。从人分离的细菌的MIC之间没有统计学差异，但对家禽皮肤样品的耐药率更高，其中25％的分离株的MIC≥160μgmL -1 。尽管将近一半的分离物在低浓度（≤1μgmL -1 ）下有毒，但其余分离物（10-400μgmL -1）却观察到了更高的MIC ），这表明该区域的大肠杆菌对碲酸钾具有广泛的抗性。

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