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Evaluation of Anti-diarrhoeal Activity of Enhydra fluctuans

机译：壶hydr波动的止泻作用评价

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The methanolic and aqueous extracts of E. fluctuans was evaluated in experimental diarrhoea, induced by castor oil in mice. Both methanolic and aqueous extracts, given orally at the dose, of 250 mg kg-1 body weight, showed significant anti-diarrhoeal activity as compared to that of the control. Both the extracts at the above dose levels also significantly reduced the intestinal transit of charcoal meal in mice. The in vitro antimicrobial activity of the extracts showed variable result. The m ethanolic extract moderately inhibited the growth of Shigella dysenteriae, Shigella boydii and Shigella flexneri , while the aqueous extract inhibited the growth of Staphylococcus aureus , S. dysenteriae and S. boydii . But both the methanolic and aqueous extracts did not show any significant effect on Escherichia coli and Pseudomonas aerugenosa . All the results indicated that the extract of E. fluctuans possesses anti-diarrhoeal activity.
机译：在小鼠腹泻诱导的实验性腹泻中评估了大肠埃希菌的甲醇提取物和水提取物。口服给予剂量为250 mg kg -1 体重的甲醇提取物和水提取物，与对照组相比均显示出显着的止泻活性。以上剂量水平的两种提取物也显着降低了小鼠木炭粉的肠道运输。提取物的体外抗菌活性显示出可变的结果。乙醇提取物适度抑制痢疾志贺氏菌，博伊氏志贺氏菌和弗氏志贺氏菌的生长，而水提取物抑制金黄色葡萄球菌，痢疾志贺氏菌和博伊氏志贺氏菌的生长。但是甲醇和水提物对大肠杆菌和铜绿假单胞菌均无明显影响。所有结果表明，大肠埃希菌的提取物具有抗腹泻活性。

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