Single Nucleotide Polymorphism Associated with Late-onset Alzheimer’s Disease

Abdulaziz Ali A. Al-Khedhairy; Misbahul Arfin; Bassam A. Alahmadi; Mohamed A. Al-Jumah

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Single Nucleotide Polymorphism Associated with Late-onset Alzheimer’s Disease

机译：单核苷酸多态性与迟发性阿尔茨海默氏病相关

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Single Nucleotide Polymorphisms (SNPs) in presenilin-1 gene (PS1) were characterized in Saudi patients afflicted with Alzheimer?s Disease (AD) using Polymerase Chain Reaction (PCR) and automated DNA sequencing methods. Genomic DNA was extracted from blood of both patients and normal individuals using organic extraction methods. Genomic DNA was amplified for all PS1 exons and intronic boundaries. Fragments were sequenced and compared with the sequences of the respective exons of normal individuals as well as the data available in GenBank. Comparison yielded the discovery of two SNPs, T56240G and T56454C in 5′ and 3′ intronic regions of exon 8 of late-onset AD Saudi patients, respectively.

机译：使用聚合酶链反应（PCR）和自动DNA测序方法对早老素-1基因（PS1）中的单核苷酸多态性（SNP）进行了阿尔茨海默病（AD）折磨的沙特患者的表征。使用有机提取方法从患者和正常人的血液中提取基因组DNA。扩增了所有PS1外显子和内含子边界的基因组DNA。对片段进行测序，并与正常个体各自外显子的序列以及GenBank中可用的数据进行比较。比较得出在晚期AD沙特患者的外显子8的5'和3'内含子区域中分别发现了两个SNP，T56240G和T56454C。

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《Journal of Medical Sciences》 |2005年第4期|共5页
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Abdulaziz Ali A. Al-Khedhairy; Misbahul Arfin; Bassam A. Alahmadi; Mohamed A. Al-Jumah;
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5. The Association of Cognitive Endophenotypes and Risky Single Nucleotide Polymorphisms of Alzheimer's Disease within the Alzheimer's Disease Neuroimaging Initiative (ADNI) Database. [D] . Jennette, Kyle J. 2015

机译：在阿尔茨海默氏病神经影像学倡议（ADNI）数据库中，阿尔茨海默氏病的认知内在表型与危险的单核苷酸多态性的关联。
6. Single-nucleotide polymorphisms of GSK3B GAB2 and SORL1 in late-onset Alzheimers disease: interactions with the APOE genotype [O] . Giselle Izzo, Orestes V. Forlenza, Bernardo dos Santos, 2013

机译：晚期阿尔茨海默氏病中GSK3BGAB2和SORL1的单核苷酸多态性：与APOE基因型的相互作用
7. Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype [O] . Izzo, Giselle, Forlenza, Orestes V., Santos, Bernardo dos, 2013

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Single Nucleotide Polymorphism Associated with Late-onset Alzheimer’s Disease

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